Nuclear signaling regulates gene expression by activating transcriptional activator proteins which can now bind to DNA.
The nucleus, home to gene expression and regulation, is the endpoint of many signaling pathways, as cells respond to stimuli by altering gene expression patterns. Nuclear signaling resultant gene expression is determined not only by hereditary information but also by epigenetic marks or modifications of DNA and associated proteins that are not necessarily inherited. Epigenetic marks are as important as DNA sequence in completing the cell’s complex signaling network. Merck has been dedicated to developing and refining nuclear signaling antibodies and assays for the study of epigenetics via mechanisms such as: