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Synaptic Transmission

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Featured Antibody
Anti-Vesicular Glutamate
Transporter 1

Localization of VGLUT1 using Anti-Vesicular Glutamate Transporter 1 (Catalog No. AB5905, green) and Synapsin (red) in rat brain Hippocampal cells thawed and cultured for 7 days. Photo courtesy of QBMCell Science.
Neuroexcitation involves electrical or chemical signals (neurotransmitters) being sent from the presynaptic neuron, across the synapse, to the postsynaptic neuron. Not surprisingly, the majority of neuropharmacological agents on the market today also act at the chemical synapse. Neurotransmitters, receptors, ion channels, and transporters are key players in neuronal function. Synaptic dynamics involving these elements regulate learning, memory, addictions, and many neurological diseases and disorders.

Merck’s antibodies from the expertise of Chemicon have facilitated studies of the relationship between neurotransmitter release, receptor activation, transmitter transport and reuptake, membrane depolarization, and neuroexcitability. Find antibodies to targets such as: GluRs, GABARs, NR1, NR2B, NR3A, KA2, ADAR, GRIK5, Serotonin, Glutamate, Dopamine, Choline, Glycine, Calcium, Sodium, Potassium, and other Transporters, AMPA, GABA, NMDA, Acetylcholine, Adrenergic, Cannabinoid receptors, GIRK channels, and many more.

Featured Neuroexcitation Mechanisms
Neurotransmitters Browse Related Antibodies Neurotransmitters are chemicals that carry signals from the presynaptic neuron, across the chemical synapse, to the postsynaptic neuron.
Reuptake and Vesicle Transporters Browse Related Antibodies The regulation of synaptic transmission depends upon manipulating the concentration and longevity of neurotransmitter in the synaptic cleft.
Postsynaptic Receptors Browse Related Antibodies The postsynaptic effect of neurotransmitter release from the presynaptic terminal depends on a specific protein receptor complex.
Broadly Distributed Receptors and Transporters Browse Related Antibodies Classical endocrine transmission and highly specialized neuronal synapses rely on the same basic components, including specific ligand release, receptor binding and ligand transporters.

Various channels in the membrane control ionic permeability within biological systems. Merck also offers numerous antibodies to channels of many types. Listed below is a subset of ion channel types typically used in neuronal imaging and ion channel research. Merck offers antibodies to targets such as: Aquaporins (AQP0 – AQP9), Calcium, Chloride, Sodium and Potassium channels, IP3 receptors, and many more.

Ion Channel Types in Neuroexcitation
Aquaporins Potassium Channels
Calcium Channels Purinergic Receptors
Chloride Channels Ryanodine Receptors
Cyclic Nucleotide-gated Cation Channels Sodium Channels
Epithelial Sodium Channels (ENaC) Transient Receptor Potential Channels
IP3 Receptors  

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