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Ubiquitous Chromatin Opening Element (UCOE®) technology gives major improvements in gene expression in stably transfected mammalian cells through effects on the structure of chromatin. UCOE® technology prevents transgene silencing and gives consistent, stable and high-level gene expression irrespective of the chromosomal integration site. UCOE® technology expression elements are small DNA elements (isolated from around house-keeping genes, which need to be active most of the time) which create a transcriptionally active open chromatin environment around an integrated transgene, maximizing its potential to be transcribed into protein irrespective of the position of the transgene in the chromosome.
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UCOE Mammalian Protein Expression
Large scale manufacture of a recombinant GFP fusion protein using conventional mammalian expression system (Left) vs. UCOE mammalian expression system (Right). UCOE technology gives major improvements in gene expression in stably transfected mammalian cells through effects on the structure of chromatin. UCOE technology prevents transgene silencing and gives consistent, stable and high-level gene expression irrespective of the chromosomal integration site yielding 20-fold higher protein expression levels than conventional vectors.