05-719 Anti-Phosphatidylserine Antibody, clone 1H6

05-719
200 µg  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Vrt FC, IHC M Purified Monoclonal Antibody
      Description
      Catalogue Number05-719
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Phosphatidylserine Antibody, clone 1H6
      OverviewSignificance:
      Anti-Phosphatidylserine may be used to detect translocation of the membrane phospholipid phosphatidylserine (PS) from the inner to the outer cell membrane leaflet; it provides an alternative to Annexin V for quantitation of apoptosis.
      Background InformationPhosphatidylserine (PS) is a phospholipid (1,2-diacyl-sn-glycerol-(3)-L-phosphoserine) found in the membrane of all plants and animals. PS is most concentrated in the brain, as PS makes up about 10% of the lipid content of neurons. Neural PS is thought to play a role in maintaining nerve cell integrity, enhancing neurotransmitter signal efficiency, and improving nerve cell signal transmission. One of the key features of apoptosis is the expresion of PS on the outer cell membrane. PS is usually found on the inner side of the plasma membrane, but during early stage apoptosis, the PS is translocated to the outer membrane. FITC-labeled annexin V can bind to the exposed PS, providing the basis of most annexin V-based apoptosis assays.
      References
      Product Information
      FormatPurified
      Control
      • Brain tissue
      PresentationPurified mouse monoclonal IgG in buffer containing 0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide and 30% glycerol. Liquid at -20°C.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Phosphatidylserine Antibody, clone 1H6 is an antibody against Phosphatidylserine for use in FC, IH.
      Key Applications
      • Flow Cytometry
      • Immunohistochemistry
      Application NotesFlow Cytometry: 0.2-2 μg/mL of a previous lot detected cell surface phosphatidylserine on Jurkat cells treated with Fas Ligand vesicles (Catalog # 01-210). See page two.

      Immunohistochemistry: This antibody has been reported by an independent laboratory to detect phosphatidylserine in rat carotid artery paraffin sections fixed with ethanol/acetone (Mandinov, L., 2003).
      Biological Information
      ImmunogenLiposomes containing 70% phosphatidylserine and 30% phosphatidylglycerol
      Cloneclone 1H6
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityRecognizes phosphatidylserine (PS) in cell membranes
      IsotypeIgG
      Species Reactivity
      • Vertebrates
      Antibody TypeMonoclonal Antibody
      Modifications
      • Phosphorylation
      Purification MethodProtein G Purified
      Molecular Weightnone given
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by flow cytometry on Jurkat cells treated with Fas Ligand vesicles (Catalog #01-210)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at from date of receipt.
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Phosphatidylserine Antibody, clone 1H6 FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-Phosphatidylserine Antibody, clone 1H6 Certificats d'analyse

      TitreNuméro de lot
      Anti-Phosphatidylserine, clone 1H6 - 2453324533
      Anti-Phosphatidylserine, clone 1H6 - 24912172491217
      Anti-Phosphatidylserine, clone 1H6 - 2768427684
      Anti-Phosphatidylserine, clone 1H6 - 2889728897
      Anti-Phosphatidylserine, clone 1H6 - 31695453169545
      Anti-Phosphatidylserine, clone 1H6 - 32127413212741
      Anti-Phosphatidylserine, clone 1H6 - 33078013307801
      Anti-Phosphatidylserine, clone 1H6 - 34385993438599
      Anti-Phosphatidylserine, clone 1H6 -27639902763990
      Anti-Phosphatidylserine, clone 1H6 -27948602794860

      Références bibliographiques

      Aperçu de la référence bibliographiqueApplicationNº PubMed
      Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration.
      Zhao, L; Zabel, MK; Wang, X; Ma, W; Shah, P; Fariss, RN; Qian, H; Parkhurst, CN; Gan, WB; Wong, WT
      EMBO molecular medicine  7  1179-97  2015

      Afficher le résumé
      26139610 26139610
      Lack of association of C-Met-N375S sequence variant with lung cancer susceptibility and prognosis.
      Shieh, JM; Tang, YA; Yang, TH; Chen, CY; Hsu, HS; Tan, YH; Salgia, R; Wang, YC
      International journal of medical sciences  10  988-94  2013

      Afficher le résumé
      23801885 23801885
      Metabolism and functions of phosphatidylserine.
      Vance, Jean E and Steenbergen, Rineke
      Prog. Lipid Res., 44: 207-34 (2005)  2005

      Afficher le résumé
      15979148 15979148
      Early membrane events in polymorphonuclear cell (PMN) apoptosis: membrane blebbing and vesicle release, CD43 and CD16 down-regulation and phosphatidylserine externalization.
      Nusbaum, P, et al.
      Biochem. Soc. Trans., 32: 477-9 (2004)  2004

      Afficher le résumé
      15157165 15157165
      The role of phosphatidylserine in recognition and removal of erythrocytes.
      Kuypers, F A and de Jong, K
      Cell. Mol. Biol. (Noisy-le-grand), 50: 147-58 (2004)  2004

      Afficher le résumé
      15095785 15095785
      Phosphatidylserine receptor and apoptosis: consequences of a non-ingested meal.
      Botto, Marina
      Arthritis Res. Ther., 6: 147-50 (2004)  2004

      15225357 15225357
      Hide and seek: the secret identity of the phosphatidylserine receptor.
      Williamson, Patrick and Schlegel, Robert A
      J. Biol., 3: 14 (2004)  2004

      Afficher le résumé
      15453906 15453906
      Apoptosis: giving phosphatidylserine recognition an assist--with a twist.
      Fadok, Valerie A and Henson, Peter M
      Curr. Biol., 13: R655-7 (2003)  2003

      12932346 12932346
      Exposure of platelet membrane phosphatidylserine regulates blood coagulation.
      Lentz, Barry R
      Prog. Lipid Res., 42: 423-38 (2003)  2003

      Afficher le résumé
      12814644 12814644
      Copper chelation represses the vascular response to injury
      Mandinov, L., et al
      Proc Natl Acad Sci U S A, 100:6700-5 (2003)  2003

      Immunohistochemistry (Tissue)12754378 12754378

      Produits & Applications associés

      Alternative Format

      Référence Description  
      16-256 Anti-Phosphatidylserine Antibody, clone 1H6, Alexa Fluor® 488 Prix & Disponibilité

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      Catégories

      Life Science Research > Antibodies and Assays > Primary Antibodies