Skip to Content

1-Benzyl-1,2,3,4-tetrahydroisoquinoline as a parkinsonism-inducing agent: a novel endogenous amine in mouse brain and parkinsonian CSF.

1-Benzyl-1,2,3,4-tetrahydroisoquinoline as a parkinsonism-inducing agent: a novel endogenous amine in mouse brain and parkinsonian CSF.

Journal of neurochemistry (1995-12-01)

Y Kotake, Y Tasaki, Y Makino, S Ohta, M Hirobe

ABSTRACT

1-Benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ) was detected as a novel endogenous amine in mouse brain and parkinsonian CSF by using the gas chromatography-selected ion-monitoring method. The level of 1BnTIQ was very high in CSF of some parkinsonian patients compared with that of controls with other neurological diseases, the mean value being three times higher (parkinsonians: 1.17 +/- 0.35 ng/ml of CSF, n = 18; vs. controls: 0.40 +/- 0.10 ng/ml of CSF, n = 11; mean +/- SEM, not significantly different). The pole test, a toxicological examination to evaluate behavior abnormalities related to Parkinson's disease, was used to examine the pharmacological effect of 1BnTIQ in mice. Repeated administration of 1BnTIQ induced behavior abnormalities, which pretreatment with 1-methyl-1,2,3,4-tetrahydroisoquinoline could prevent. We suggest that 1BnTIQ may be related to the idiopathic Parkinson's disease.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

S-(5′-Adenosyl)-L-homocysteine, crystalline

Aluminum, IRMM^®, certified reference material, 1.0 mm wire

Titanium, IRMM^®, certified reference material, 0.5 mm foil

Sigma-Aldrich

Zinc, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.9%, granular

Titanium, IRMM^®, certified reference material, 0.5 mm wire

Sigma-Aldrich

Magnesium, powder, ≥99%

Sigma-Aldrich

Magnesium, ribbon, ≥99.0% Mg basis

Sigma-Aldrich

Magnesium, grit, ≥99.0% (KT)

Sigma-Aldrich

Copper, foil, ≥99.8% (complexometric)

SAFC

L-Cystine

Aluminum, IRMM^®, certified reference material, 1.0 mm foil

Sigma-Aldrich

Molybdenum, powder, <150 μm, 99.99% trace metals basis

Sigma-Aldrich

Cobalt, foil, thickness 0.1 mm, 99.95% trace metals basis

Sigma-Aldrich

Chromium, chips, 99.995% trace metals basis

Sigma-Aldrich

Cobalt, foil, thickness 1.0 mm, 99.95% trace metals basis

Sigma-Aldrich

Titanium, wire, diam. 0.81 mm, 99.7% trace metals basis

Continuous cast copper (O), BCR^®, certified reference material, rod

Sigma-Aldrich

Zirconium, sponge, ≥99% trace metals basis

Sigma-Aldrich

Zinc, pieces, 2-14 mesh, 99.9% trace metals basis

Sigma-Aldrich

Zinc, sticks, diam. 7-10 mm, 99.97% trace metals basis

Sigma-Aldrich

Tungsten, powder, 12 μm, 99.9% trace metals basis

Sigma-Aldrich

Molybdenum, powder, 10 μm, ≥99.95% trace metals basis

Sigma-Aldrich

Nickel, rod, diam. 6.35 mm, ≥99.99% trace metals basis

Sigma-Aldrich

Titanium, wire, diam. 1.0 mm, 99.99% trace metals basis

Sigma-Aldrich

Cobalt, foil, thickness 0.1 mm, ≥99.99%

Sigma-Aldrich

Zinc preparation, 5 g/dL Zn²⁺ in THF, highly reactive Rieke^®metal

Sigma-Aldrich

Magnesium preparation, Highly Reactive Rieke^® Metal, suspension, 2.5 g in THF

Sigma-Aldrich

Copper, wire, diam. 0.64 mm, 99.995% trace metals basis

Sigma-Aldrich

Nickel, foil, thickness 0.1 mm, 99.98% trace metals basis

Sigma-Aldrich

Copper, wire, diam. 0.25 mm, 99.999% trace metals basis