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Automated Chemical Synthesis

Automated chemical synthesis enables end-to-end handling of reaction setup, execution, workup, isolation, and purification by programmable systems. Using automation and digital controls, these platforms produce small molecules and other organic compounds with improved speed, efficiency, and reproducibility. Reducing manual steps can lower operator error and contamination risk, improve safety, and allow researchers to focus on experimental design and analysis.

In partnership with SynpleChem, we provide an automated synthesis platform for drug discovery, medicinal chemistry, and general chemical synthesis. The system combines a benchtop synthesizer with pre-filled reagent cartridges. Users add the starting material, select a cartridge, and start the run; the instrument manages reaction execution, workup, and product isolation/purification. An automated wash sequence prepares the instrument for subsequent runs and helps reduce cross-contamination, supporting parallel or sequential experiments and routine optimization.

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Explore our wide selection of reagent cartridges featuring distinct reaction classes, with more than 40 different reagents:

  • N-Heterocycle formation (SnAP) – converts a broad range of aldehydes into N-heterocycles
  • Reductive amination – transforms aldehydes or ketones and primary or secondary amines into complex amines
  • Protein Degrader formation – designed for PROTAC® synthesis with a variety of PEG linker lengths and either VHL or CRBN ligands
  • Biotin tags – attaches Biotin tags to either aldehydes/ketones via reductive amination or amines via acylation
  • Mitsunobu – forms carbon-carbon bonds through dehydrative coupling of a primary or secondary alcohol
  • Boc protection – provices Boc protection of primary and secondary amines
  • Boc deprotection – removes Boc protection of amines into free amine salts
  • Fluorination – transforms primary and secondary alcohols into corresponding fluorinated product
  • Silyl deprotection – removes silyl protecting groups
  • Amide formation – couples amines and carboxylic acids
  • Suzuki Coupling – couples aryl halides with aryl boronic acids
  • Nosyl Protection – provides o-Ns protection of primary/secondary amines and amine salts
  • Cbz Protection – provides N-Cbz protection of primary/secondary amines and amine salts

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Related Videos

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Synple 2 Automated Cleaning Video
Synple 2 Automated Cleaning Video
After your product is generated, the synthesizer performs automated washing so it’s contamination-free and ready for your next synthesis.
Synple Comparison Video
Synple Comparison Video
Unparalleled speed: While manual chemical synthesis can take up to several hours to complete, Synple 2 just requires 5 to 10 minutes of the user’s time.
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