C2313
Compound 48/80
powder, hypotensive agent
Synonym(s):
Poly-p-methoxyphenethylmethylamine
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About This Item
UNSPSC Code:
41106300
NACRES:
NA.77
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Application
Compound 48/80 has been used:
- to stimulate hemocytes for histamine release for measurement in ELISA and flow cytometry
- to induce mast cell degranulation
- to induce anaphylactic activity, dermatitis, pruritis, inflammation in mice
Biochem/physiol Actions
Compound 48/80 (C 48/80) is a hypotensive agent, which promotes release of histamine. C 48/80 reduces the phagocytic ability of hemocytes in Styela plicata. C 48/80 promotes degranulation of mast cells. It Inhibits calmodulin, phospholipase C, endoplasmic reticulum (ER) Ca2+ ATPase and activates G proteins.
General description
Compound 48/80, is the condensation product of N-methyl p-methoxyphenethylamine and formaldehyde.
Preparation Note
Condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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C Bronner et al.
Biochimica et biophysica acta, 920(3), 301-305 (1987-08-15)
Compound 48/80 inhibited phosphatidylinositol-specific phospholipase C activity from human platelets. Whereas 1 microgram/ml of compound 48/80 slightly stimulated Ca2+-dependent phospholipase A2, higher concentrations led to dose-dependent inhibition of this platelet enzyme. This biphasic effect was confirmed with phospholipases A2 purified
Histamine regulates the inflammatory response of the tunicate Styela plicata
Garcia-Garcia E, et al.
Developmental and Comparative Immunology, 46(2), 382-391 (2014)
Development of a short-term canine full-thickness skin organ culture method under serum-free conditions
Abramo F, et al.
American Journal of Animal and Veterinary Sciences, 11(2), 61-69 (2016)
Antiallergic activity of Aristolochia bracteolata Lank in animal model
Chitme HR, et al.
Indian Journal of Experimental Biology, 48, 46-52 (2010)
Y Koibuchi et al.
European journal of pharmacology, 115(2-3), 163-170 (1985-09-24)
Compound 48/80 and 14C-labeled compound 48/80 were synthesized, and fractionated by thin-layer chromatography into 14 components (A-N) with various histamine releasing activities and different Ca2+ requirements for their actions. The histamine release induced from rat mast cells in vitro by
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