Clarification Depth Filters & Pretreatment Solutions
Our clarification portfolio provides flexibility to the biopharma manufacturer for efficient cell, cellular debris and other insoluble contaminant removal and impurity clearance from different process streams from process development through large-scale manufacturing. Millistak+®, Millistak+® HC Pro and Clarisolve® Depth filters are available in Pod devices.
Millistak+® HC Pro Filters
MILLISTAK+® HC PRO FILTERS
These are high capacity fully synthetic depth filters for primary and secondary clarification and downstream polishing applications.
Millistak+® Depth Filters
Millistak+® Depth Filters
These filters are offered in both Pod and lenticular formats.
- Millistak+® HC filters combine multiple layers of charged depth media for enhanced particulate retention and filter capacity for clarification and polishing applications.
- Millistak+® Carbon offers enhanced impurity clearance for turbidity reduction and polishing.
- Millistak+® DE filters are single layer clarification filters containing diatomaceous earth and a charged resin binder.
- Millistak+® CE filters are single layer clarification filters containing cellulose.
Clarisolve® Depth Filters and Flocculation Polymers
Clarisolve® depth filters offer a gradient density structure designed for efficient primary clarification of pretreated cell culture harvests.
- Clarisolve® mPAA modified poly (allyl amine) is a stimulus-responsive polymer for flocculation of high cell density cell culture harvests.
- pDADMAC (poly(diallyldimethyl-ammonium chloride) is a cationic polymer for flocculation of cellular debris.
Support for Qualification, Risk Assessment, and Process Optimization
Complementing our product portfolio, the Emprove® Program provides three types of dossiers to support different stages of development and manufacturing operations such as qualification, risk assessment, and process optimization. The dossiers consolidate comprehensive product-specific testing data, quality statements, and regulatory information in a readily available format to simplify your compliance needs.
Related Product Resources
Product Operations
Article: Generic Process of Virus-Like Particle (VLP) Based Vaccine Manufacturing
Article: Complete Clarification Solution for Processing High Density Cell Culture
Article: Selection of Clarification Methods for Improved Downstream Performance and Economics
Article: Evolving Clarification Strategies to Meet New Challenges
Article: Industrial Application of Impurity Flocculation to Streamline Antibody Purification Processes
Article: Development of a Novel and Efficient Cell Culture Flocculation Process Using a Stimulus Responsive Polymer to Streamline Antibody Purification Processes
Millistak+® Pod Disposable Depth Filter Performance Guide
Application Note: Clarisolve® mPAA Stimulus-responsive Polymer Flocculant for Use with Clarisolve® 60 HX Depth Filters
Application Note: Millistak+® Activated Carbon for mAb Downstream Purification
Application Note: pDADMAC Flocculant Reagent for Use with Clarisolve® Depth Filters
Product Selection
Clarification Portfolio Guide
Flyer: Millistak+® Family and Clarisolve® Depth Filters at a Glance
Flyer: Clarification of Mammalian Cell Cultures by Depth Filtration
Product Specifications
Data Sheet: Millistak+® HC Pro
Data Sheet: Millistak+® Pod Disposable Depth Filter System
Data Sheet: Millistak+® Pod Carbon Depth Filter Media System
Data Sheet: Clarification Solutions for Pre-treated Feed Streams
Chart: Millistak+® Filter Chemical Compatibility
Products
Highlights
How to standardize the process development approach for a two-step clarification process ensuring development of a robust, scalable unit operation.
pDADMAC for pretreatment of mammalian cell culture harvest utilizing Clarisolve® depth filters for improved primary & secondary clarification of flocculated feeds.
A comprehensive holistic assessment of Clarisolve® mPAA flocculation polymer pre-treatment for clarification & subsequent downstream chromatography steps.