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  • Tympanoplasty graft preparation using ear drops containing polyethylene glycol, flumethasone and clioquinol.

Tympanoplasty graft preparation using ear drops containing polyethylene glycol, flumethasone and clioquinol.

The Journal of laryngology and otology (2011-07-07)
R J List, E P Flook, H L Tay
ABSTRACT

The aim of tympanoplasty graft preparation is to stiffen the fascia or perichondrium and thereby to optimise ease of manipulation. We report 39 cases utilising a novel technique in which the graft is prepared in ear drops containing polyethylene glycol, flumetasone pivalate (0.02 per cent) and clioquinol (1 per cent). This technique is useful in reducing the risk of desiccation if placement is delayed, and may pose less risk of infection and mechanical damage than alternative methods.

MATERIALS
Product Number
Brand
Product Description

Supelco
Clioquinol, VETRANAL®, analytical standard
Sigma-Aldrich
5-Chloro-7-iodo-8-quinolinol, ≥95.0% (HPLC)
Sigma-Aldrich
Flumethasone
Clioquinol, European Pharmacopoeia (EP) Reference Standard