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407950 Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem

Ionomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is an ionophore with high specificity for divalent cations. More effective than A23187 as a mobile ion carrier for Ca2+.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      56092-81-0C₄₁H₇₂O₉
      Description
      OverviewHighly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5. In contrast to A23187, it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest in the G1 phase in mature Burkitt lymphoma cell lines.
      Absorption max. (280 nm, MeOH): 18,600 M-1cm-1.
      Catalogue Number407950
      Brand Family Calbiochem®
      References
      ReferencesAagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
      Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
      Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
      Lee, H.C. 1993. J. Biol. Chem. 268, 293.
      Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
      Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
      Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.
      Product Information
      CAS number56092-81-0
      ATP CompetitiveN
      FormWaxy solid
      Hill FormulaC₄₁H₇₂O₉
      Chemical formulaC₄₁H₇₂O₉
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationIonomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is an ionophore with high specificity for divalent cations. More effective than A23187 as a mobile ion carrier for Ca2+.
      Biological Information
      Primary TargetMobile ion carrier for Ca2+
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSNO0600000
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 year at 4°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      407950 0

      Documentation

      Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      407950

      References

      Reference overview
      Aagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
      Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
      Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
      Lee, H.C. 1993. J. Biol. Chem. 268, 293.
      Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
      Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
      Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure

      Citations

      Title
    • Jonathan Rios-Doria, et al. (2004) Cleavage of b-catenin by calpain in prostate and mammary tumor cells. Cancer Research 64, 7237-7240.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-April-2010 JSW
      DescriptionHighly specific for divalent cations (Ca2+ > Mg2+ >> Sr2+ = Ba2+). More effective than antibiotic A23187 as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5, causing significant absorption in the UV range; however, in contrast to A23187 (Cat. No. 100105), it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons. Also induces cell cycle arrest in the G1 interval of mature Burkitt lymphoma cell lines.
      FormWaxy solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number56092-81-0
      RTECSNO0600000
      Chemical formulaC₄₁H₇₂O₉
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (10 mg/ml) and Methanol (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 year at 4°C.
      Toxicity Harmful
      ReferencesAagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
      Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
      Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
      Lee, H.C. 1993. J. Biol. Chem. 268, 293.
      Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
      Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
      Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.
      Citation
    • Jonathan Rios-Doria, et al. (2004) Cleavage of b-catenin by calpain in prostate and mammary tumor cells. Cancer Research 64, 7237-7240.
      		•

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Biochemicals > Ionophores