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Cardiovascular Disease Biomarker Assay Kits Using Luminex® Technology

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Related Resources: Analyte Quarterly | Application NotesPosters
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Merck:/Freestyle/BI-Bioscience/Protein-Detection/bmia-images/pecam-2.jpgCardiovascular Biomarker Application Note

Measurement of cardiovascular disease biomarkers in human samples using magnetic bead-based MILLIPLEX® multiplex panels

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Measure cardiovascular biomarkers – such as fibrinogen, CRP, and myeloperoxidase – with MILLIPLEX® multiplexed assay kits.
Cardiovascular disease (CVD), particularly atherosclerotic vascular disease, is a leading cause of global mortality, accounting for 30% of all deaths annually (WHO). Inflammation pathways play a vital role in the initiation, maintenance and progression of vascular disease, and there is a strong correlation between inflammation biomarkers (such as acute phase proteins) and prognosis in coronary artery disease.

Bring your cardiovascular disease biomarkers to life with MILLIPLEX® Multiplex CVD Assays

For a complete picture of CVD, you need to analyze data for multiple proteins from multiple systems. Trust Merck’s growing MILLIPLEX® portfolio of multiplexed CVD biomarker assays for precise lot-to-lot consistency.

Based on Luminex xMAP® technology, our analytically verified assay kits provide:
  • Standards verified to match reference lots
  • Serum matrix for generating standard curves that accurately simulate conditions of native analyte conditions in serum or plasma
  • In-assay controls
  • Detection antibody cocktails to ensure consistent performance regardless of plex size
Some examples of the cardiovascular disease biomarker assay analytes in our portfolio are listed below.

Cardiovascular Disease Biomarkers*:

Biomarkers that may indicate a higher risk for heart disease include:

Troponin I Troponin T BNP (B-type natriuretic peptide)
NT-proBNP sICAM-1 Myeloperoxidase
*only selected analytes listed

Acute Phase Proteins*:

Acute phase proteins are produced in the liver in response to proinflammatory cytokines. The serum concentrations of these proteins change significantly in response to inflammation, and low-grade inflammation has been correlated with cardiovascular disease.

CRP Fibrinogen Serum Amyloid P
α-1-Acid-Glycoprotein (AGP) α-2-Macroglobulin L-Selectin
*only selected analytes listed


These proteins bind to and transport lipids through the bloodstream; their levels may correlate with risk of coronary heart disease.

Apo AI Apo AII Apo B
Apo CII Apo CIII Apo E

Cardiovascular heart disease may be coincident with metabolic syndrome. Simultaneously measure biomarkers of both disease states by choosing among MILLIPLEX® metabolism biomarker assay kits.

Numerous studies have demonstrated an association between the inflammation pathway and cardiovascular risk factors. Enrich your CVD studies by adding MILLIPLEX® inflammation assay panels to your experiments.

Download the Analyte Quarterly brochure for a complete, updated list of assays.

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Biomarkers play a significant role in both normal and disease states and you need a reliable partner for quality assays and consistent performance. Our multiplex, ELISA and RIA biomarker assays provide you with consistent, high-quality tools so that you can do your best work while saving time, labor and cost. Use the assay finder below to choose the correct assay for your biomarker of interest, so you can obtain the best quality data the first time.
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