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5.05875

(+)-Bicuculline

Name: (+)-Bicuculline
Brand: MM

Sinónimos:

(+)-Bicuculline, GABA _A Receptor Antagonist, Bicuculline

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Fórmula empírica (notación de Hill):

C₂₀H₁₇NO₆

Número CAS:

485-49-4

Peso molecular:

367.35

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00005006

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Propiedades

assay

≥98% (HPLC)

Quality Segment

100

form

solid

potency

740 nM IC₅₀

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

pale yellow

solubility

DMSO: soluble

storage temp.

−20°C

SMILES string

N1([C@@H](c5c(cc6c(c5)OCO6)CC1)[C@@H]2OC(=O)c3c4c(ccc32)OCO4)C

InChI

1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1

InChI key

IYGYMKDQCDOMRE-ZWKOTPCHSA-N

Descripción

General description

A potent allosteric antagonist of vertebrate GABA_A receptors. Blocks GABA_A-induced chloride currents in cultured neurons (IC₅₀ = 740 nM). Shown to increase blood pressure in spontaneously hypertensive rats and cause convulsion in experimental animals. Also, increases the amplitude of spontaneous colonic contractions.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Ueno, S., et al. 1997. J. Neurosci.17, 625.
Uchida, I., et al. 1996. Eur. J. Pharmacol.307, 89.
Minocha, A., and Galligan, J.J. 1993. Eur. J. Pharmacol.230, 187.
Robert K.A., et al. 1993. Cardiovasc. Pharmacol.21, 156.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

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pictograms

GHS06,GHS09

signalword

Danger

pcodes

P260 - P262 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c