- A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.
A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.
Organic letters (2014-06-17)
Xiaowen Xu, Min Zhang, Huanfeng Jiang, Jia Zheng, Yiqun Li
PMID24933098
ABSTRACT
A novel straightforward synthesis of both symmetrical and unsymmetrical 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF as a one-carbon synthon has been developed. The presented method allows synthesizing the products that are currently inaccessible or challenging to prepare with the advantages of operational simplicity, broad substrate scope, and no need for prefunctionalized reagents, making it a highly practical approach to access various 2,4-disubstituted-1,3,5-triazines.
MATERIALS
Product Number
Brand
Product Description
Copper, tube, 1000mm, outside diameter 6.0mm, inside diameter 4mm, wall thickness 1.0mm, as drawn, 99.9%
Copper - O.F.H.C., rod, 200mm, diameter 25.4mm, as drawn, 99.95+%
Copper - O.F.H.C., tube, 500mm, outside diameter 0.9mm, inside diameter 0.56mm, wall thickness 0.17mm, 99.95+%
Copper - O.F.H.C., foil, light tested, 50x50mm, thickness 0.010mm, hard, 99.95+%
Copper - O.F.H.C., foil, 6mm disks, thickness 0.7mm, half hard, 99.95+%
Copper, wire reel, 50m, diameter 0.1mm, annealed, 99.9%
Copper - O.F.H.C., foil, light tested, 150x150mm, thickness 0.05mm, hard, 99.95+%
Copper - O.F.H.C., foil, light tested, 25x25mm, thickness 0.075mm, half hard, 99.95+%
Copper - O.F.H.C., foil, 8mm disks, thickness 0.25mm, half hard, 99.95+%
Copper - O.F.H.C., rod, 25mm, diameter 25.4mm, as drawn, 99.99+%
Copper - O.F.H.C., tube, 200mm, outside diameter 3.92mm, inside diameter 3.72mm, wall thickness 0.1mm, 99.95+%
Copper - O.F.H.C., foil, 8mm disks, thickness 0.006mm, hard, 99.95+%
Copper - O.F.H.C., tube, 1000mm, outside diameter 0.38mm, inside diameter 0.22mm, wall thickness 0.08mm, 99.95+%
Copper - O.F.H.C., foil, light tested, 25x25mm, thickness 0.010mm, hard, 99.95+%
Copper - O.F.H.C., foil, 8mm disks, thickness 0.5mm, half hard, 99.95+%
Copper - O.F.H.C., rod, 100mm, diameter 6.35mm, as drawn, 99.95+%
Copper - O.F.H.C., foil, light tested, 150x150mm, thickness 0.05mm, annealed, 99.95+%
Copper - O.F.H.C., tube, 100mm, outside diameter 3.92mm, inside diameter 3.72mm, wall thickness 0.1mm, 99.95+%
Copper - O.F.H.C., rod, 100mm, diameter 25.4mm, as drawn, 99.99+%
Copper - O.F.H.C., sheet, 150x150mm, thickness 4.76mm, 99.95+%
Copper - O.F.H.C., rod, 500mm, diameter 16mm, as drawn, 99.95+%
Copper - O.F.H.C., tube, 1000mm, outside diameter 0.9mm, inside diameter 0.56mm, wall thickness 0.17mm, 99.95+%
Copper - O.F.H.C., foil, light tested, 25x25mm, thickness 0.05mm, annealed, 99.95+%
Copper - O.F.H.C., tube, 200mm, outside diameter 0.635mm, inside diameter 0.275mm, wall thickness 0.18mm, 99.95+%
Copper - O.F.H.C., foil, 8mm disks, thickness 0.1mm, hard, 99.95+%
Copper - O.F.H.C., tube, 100mm, outside diameter 0.38mm, inside diameter 0.22mm, wall thickness 0.08mm, 99.95+%
Copper - O.F.H.C., sheet, 150x150mm, thickness 6.35mm, 99.95+%
Copper - O.F.H.C., rod, 100mm, diameter 76mm, as drawn, 99.95+%
Copper - O.F.H.C., foil, light tested, 100x100mm, thickness 0.075mm, half hard, 99.95+%
Copper - O.F.H.C., tube, 100mm, outside diameter 10mm, inside diameter 8mm, wall thickness 1.0mm, 99.95+%