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AB2209 Anti-ABBA Antibody

Anti-ABBA Antibody is an antibody against ABBA for use in WB, IC, IH.

Anti-ABBA Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neuronal & Glial Markers Gene Symbol: MGC79213 , ABBA UniProt Number: Q6P9S0
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AB2209
100 µL  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, ICC, IHCRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB2209
      DescriptionAnti-ABBA Antibody
      Alternate Names
      • actin-bundling protein with BAIAP2 homology
      Background InformationRadial glia play key roles in neuronal migration, axon guidance, and neurogenesis during development of the central nervous system. However, the molecular mechanisms regulating growth and morphology of these extended cells are unknown. ABBA, a novel member of the IRSp53/MIM protein family, is enriched in different types of radial glia. ABBA binds ATP-actin monomers with high affinity and deforms PIP2-rich membranes in vitro through its WH2 and IMdomains, respectively. In radial glia-like C6-R cells, ABBA localizes to the interface between the actin cytoskeleton and plasma membrane, and its depletion by RNAi leads to defects in lamellipodial dynamics and process extension. Together, ABBA acts as a novel regulator of actin and plasma membrane dynamics in radial glial cells, and provides evidence that the membrane binding/deformation activity is critical for the cellular functions of IRSp53/MIM/ABBA family proteins
      References
      Product Information
      FormatSerum
      Control
      • Mouse brain lysate
      PresentationSerum with with 0.05% NaN3
      Quality LevelMQ100
      Applications
      ApplicationAnti-ABBA Antibody is an antibody against ABBA for use in WB, IC, IH.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunohistochemistry
      Application NotesNon-Lot Specific Tested Application 1:
      Immunocytochemistry: 1:50 dilution in mouse primary glial cell line and C6, C6-R rat cell line.

      Non-Lot Specific Tested Application 2:
      Immunohistochemistry: 1:1,000 in embryonic and adult brain tissue.

      (See Reference for more information)
      Biological Information
      ImmunogenRecombinant protein.
      HostRabbit
      SpecificityCat. # AB2209 recognizes ABBA
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteHuman, Mouse and Rat. May react with Pan troglodytes and Macaca mulatta based on sequence homology. Reactivity with other species was not tested.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MGC79213
      • ABBA
      UniProt Number
      Molecular Weight~82 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely tested on mouse brain lysate
      Lot Specific Tested Application 1: Western Blot
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB2209 04053252672910

      Documentation

      Anti-ABBA Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-ABBA Antibody Certificates of Analysis

      TitleLot Number
      Anti-ABBA - NG1539631 NG1539631

      References

      Reference overviewPub Med ID
      ABBA regulates plasma-membrane and actin dynamics to promote radial glia extension.
      Saarikangas, Juha, et al.
      J. Cell. Sci., 121: 1444-54 (2008)  2008

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