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MABT187 Anti-Kindlin-3 Antibody, clone 181A

Anti-Kindlin-3 Antibody, clone 181A is an antibody against Kindlin-3 for use in Western Blotting.

Anti-Kindlin-3 Antibody, clone 181A MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Cytoskeleton Gene Symbol: FERMT3, KIND3, MIG2B, URP2 UniProt Number: Q86UX7
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MABT187
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABT187
      DescriptionAnti-Kindlin-3 Antibody, clone 181A
      Alternate Names
      • Fermitin family homolog 3
      • Kindlin-3
      • MIG2-like protein
      • Unc-112-related protein 2
      Background InformationKindlin-3 is an intracellular protein encoded by the FERMT3 gene and which binds directly to the β chain cytoplasmic tail of integrin in hematopoietic cells. This protein belongs to a family of adhesion plaque proteins, of which there are three members, which act to activate integrins. Kindlin-3 differs from Kindlins-1 and -2 in that its expression is restricted to hematopoietic systems and is especially high in spleen and megakaryocytes. It is a necessary component for integrin activation and for platelet aggregation. Mutations in FERMT3 and consequently to the encoding of Kindlin-3 protein are causal to LAD-I variant syndrome, an uncommon genetic disorder in which integrin adhesive functions on platelets and leukocytes are disrupted.
      References
      Product Information
      FormatPurified
      Control
      • K562 cell lysate
      PresentationPurified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Kindlin-3 Antibody, clone 181A is an antibody against Kindlin-3 for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenHis-tagged recombinant protein corresponding to human Kindlin-3.
      Clone181A
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FERMT3
      • KIND3
      • MIG2B
      • URP2
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~76 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in K562 cell lysate.

      Western Blot Analysis: A 1:1,000 dilution of this antibody detected Kindlin-3 in 10 µg of K562 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABT187 04053252649622

      Documentation

      Anti-Kindlin-3 Antibody, clone 181A SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Kindlin-3 Antibody, clone 181A Certificates of Analysis

      TitleLot Number
      Anti-Kindlin-3, clone 181A 2480966
      Anti-Kindlin-3, clone 181A - 2454743 2454743
      Anti-Kindlin-3, clone 181A - 2462915 2462915
      Anti-Kindlin-3, clone 181A - 3225743 3225743
      Anti-Kindlin-3, clone 181A - 3697336 3697336
      Anti-Kindlin-3, clone 181A - Q2050288 Q2050288
      Anti-Kindlin-3, clone 181A -2745867 2745867
      Anti-Kindlin-3, clone 181A -2757861 2757861
      Anti-Kindlin-3, clone 181A Monoclonal Antibody 2922354

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies