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MAB5386X Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor® 488

This Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor 488 is validated for use in FC, IC for the detection of Nerve Growth Factor Receptor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurochemistry & Neurotrophins Gene Symbol: NGFR, p75(NTR), TNFRSF16, Gp80-LNGFR, CD271 UniProt Number: P08138
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MAB5386X
50 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Po, Rb, ShFC, ICCMAlexaFluor®488Monoclonal Antibody
      Description
      Catalogue NumberMAB5386X
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor® 488
      Background InformationThe low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells
      References
      Product Information
      FormatAlexaFluor®488
      PresentationLiquid. Contains no preservative.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor 488 is validated for use in FC, IC for the detection of Nerve Growth Factor Receptor.
      Key Applications
      • Flow Cytometry
      • Immunocytochemistry
      Application NotesOptimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenHuman melanoma cell line.
      CloneME20.4
      HostMouse
      SpecificityReacts with the low affinity nerve growth factor receptor (NGFR p75). The epitope recognized by the antibody maps within the third or fourth cysteine-rich repeats of the NGFR molecule. Reactivity has not been observed with rat, chicken, or mouse NGFR.
      IsotypeIgG1
      Species Reactivity
      • Human
      • Pig
      • Rabbit
      • Sheep
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryNerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain.
      Gene Symbol
      • NGFR
      • p75(NTR)
      • TNFRSF16
      • Gp80-LNGFR
      • CD271
      Non-Reactive Species
      • Chicken
      • Mouse
      • Rat
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08138 # Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
      SIZE: 427 amino acids; 45183 Da
      SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      DOMAIN: SwissProt: P08138 Death domain is responsible for interaction with RANBP9.
      PTM: N- and O-glycosylated. & O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. & Phosphorylated on serine residues.
      SIMILARITY: Contains 1 death domain. & Contains 4 TNFR-Cys repeats.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsAliquot and store at -20 ºC, or glycerol (ASC grade or better) can be added (1:1) and the antibody stored at -20ºC for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MAB5386X 04053252318269

      Documentation

      Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor® 488 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Nerve Growth Factor Receptor Antibody, p75, Alexa Fluor® 488 Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-NERVE GROWTH FACTOR-RECEPTOR, p75 ALEXA FLUOR 488 CONJUGATED MONOCLONAL ANTIBODY - 2424664 2424664
      MOUSE ANTI-NERVE GROWTH FACTOR-RECEPTOR, p75 - 3221496 3221496
      MOUSE ANTI-NERVE GROWTH FACTOR-RECEPTOR, p75 -2759713 2759713
      MOUSE ANTI-NERVE GROWTH FACTOR-RECEPTOR, p75 ALEXA FLUOR 488 CONJUGATED - 3293710 3293710
      MOUSE ANTI-NERVE GROWTH FACTOR-RECEPTOR, p75 ALEXA FLUOR#210; 488 CONJUGATED MONOCLONAL ANTIBODY - 2211004 2211004
      MOUSE ANTI-NERVE GROWTH FACTOR-RECEPTOR, p75 ALEXA FLUOR® 488 CONJUGATED MONOCLONAL ANTIBODY 2975910
      MOUSE ANTI-NERVE GROWTH FACTOR-RECEPTOR, p75 ALEXA FLUOR® 488 CONJUGATED MONOCLONAL ANTIBODY 3077396
      MOUSE ANTI-NERVE GROWTH FACTOR-RECEPTOR, p75 ALEXA FLUOR®488 CONJUGATED MONOCLONAL ANTIBODY 3068076

      References

      Reference overviewPub Med ID
      Distribution and co-localization of choline acetyltransferase and p75 neurotrophin receptors in the sheep basal forebrain: implications for the use of a specific cholinergic immunotoxin
      Ferreira, G, et al
      Neuroscience, 104:419-39 (2001)  2001

      		11377845 11377845
      Antibody for human p75 LNTR identifies cholinergic basal forebrain of non-primate species
      Tremere, L A, et al
      Neuroreport, 11:2177-83 (2000)  2000

      		10923666 10923666
      Characterization of nerve growth factor receptor in neural crest tumors using monoclonal antibodies
      Ross, A H, et al
      Proc Natl Acad Sci USA, 81:6681-5 (1984)  1984

      		6093111 6093111

      Data Sheet

      Title
      MOUSE ANTI-NERVE GROWTH FACTOR-RECEPTOR, p75 ALEXA FLUOR® 488 CONJUGATED MONOCLONAL ANTIBODY

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies