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AB10535 Anti-Neurogenin-3 (rabbit) Antibody

Detect Neurogenin-3 (rabbit) using this Anti-Neurogenin-3 (rabbit) Antibody validated for use in WB, IH.

Anti-Neurogenin-3 (rabbit) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: NEUROG3, ATOH5, Atoh5, ngn3, NGN3, MATH4B, Math4B UniProt Number: P70661
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AB10535
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWB, IHCRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB10535
      DescriptionAnti-Neurogenin-3 (rabbit) Antibody
      Alternate Names
      • Neurogenin 3
      • NGN3
      • Neurogenin3
      Background InformationNeurogenins are a family of bHLH transcription factors involved in specifying neuronal differentiation. They are related to Drosophila atonal. The neurogenins (ngns) make up one of these atonal-related gene families. In neural crest cells, the atonal-related neurogenin family is particularly important for the sensory lineage (Neurogenins Are Essential for the Formation of dorsal root ganglia), while the achaete-scute homologue ash1 (Mash1) is important for aspects of autonomic neurogenesis (mash1 is essential for noradrenergic differentiation). Neurogenin-3 also promotes pancreatic development.
      References
      Product Information
      FormatSerum
      Control
      • mNgn3 transfected and wildtype rabbit reticulocyte lysates
      PresentationUnpurified rabbit polyclonal serum containing 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Neurogenin-3 (rabbit) using this Anti-Neurogenin-3 (rabbit) Antibody validated for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:500 dilution from a previous lot detected Neurogenin-3 in mouse embryo E12.5+ tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the N-terminus of mouse Neurogenin-3.
      EpitopeN-terminus
      HostRabbit
      SpecificityThis antibody recognizes Neurogenin-3 at the N-terminus.
      IsotypeIgG
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NEUROG3
      • ATOH5
      • Atoh5
      • ngn3
      • NGN3
      • MATH4B
      • Math4B
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types.

      SUBUNIT STRUCTURE: Efficient DNA binding requires dimerization with another bHLH protein.

      SUBCELLULAR LOCATION: Nucleus Potential.

      SEQUENCE SIMILARITIES: Contains 1 basic helix-loop-helix (bHLH) domain.
      Molecular Weight32 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in mNgn3 transfected and wildtype rabbit reticulocyte lysates.

      Western Blot Analysis: A 1:1,000 dilution of this antibody detected Neurogenin-3 on 10 µg of mNgn3 transfected rabbit reticulocyte lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB10535 04053252517495

      Documentation

      Anti-Neurogenin-3 (rabbit) Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Neurogenin-3 (rabbit) Antibody Certificates of Analysis

      TitleLot Number
      Anti-Neurogenin-3 (rabbit polyclonal) 3170252
      Anti-Neurogenin-3 (rabbit polyclonal) 2830885
      Anti-Neurogenin-3 (rabbit polyclonal) 2868365
      Anti-Neurogenin-3 (rabbit polyclonal) - 2420541 2420541
      Anti-Neurogenin-3 (rabbit polyclonal) - 2064316 2064316
      Anti-Neurogenin-3 (rabbit polyclonal) - 2198976 2198976
      Anti-Neurogenin-3 (rabbit polyclonal) - 4108585 4108585
      Anti-Neurogenin-3 (rabbit polyclonal) - NG1820267 NG1820267
      Anti-Neurogenin-3 (rabbit polyclonal) - NG1865074 NG1865074
      Anti-Neurogenin-3 (rabbit polyclonal) - NRG1744363 NRG1744363
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