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MABS36 Anti-ODC1 Antibody, clone CPTC-ODC1-2

This Anti-ODC1 Antibody, clone CPTC-ODC1-2 is validated for use in WB for the detection of ODC1.

Anti-ODC1 Antibody, clone CPTC-ODC1-2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Gene Symbol: ODC1 UniProt Number: P11926
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MABS36
200 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS36
      DescriptionAnti-ODC1 Antibody, clone CPTC-ODC1-2
      Alternate Names
      • ornithine decarboxylase 1
      • ornithine decarboxylase
      Background InformationOrnithine decarboxylase (ODC1) is the first enzyme in polyamine synthesis and is mandatory for normal growth and is increased in many types of cancers. ODC1 has been shown to suppress the fmc1 deletion in yeast and restores healthy respiratory growth. ODC1 may play a role in promoting DNA synthesis in hepatocytes.
      References
      Product Information
      FormatPurified
      Control
      • MCF-7 cell lysate
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-ODC1 Antibody, clone CPTC-ODC1-2 is validated for use in WB for the detection of ODC1.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenFull length of recombinant protein corresponding to human ODC1.

      Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program.
      CloneCPTC-ODC1-2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. [provided by RefSeq].
      Gene Symbol
      • ODC1
      Purification MethodProtein G
      UniProt Number
      UniProt SummaryCATALYTIC ACTIVITY: L-ornithine = putrescine + CO2.

      COFACTOR: Pyridoxal phosphate.

      ENZYME REGULATION: Inhibited by S-nitrosylation.

      PATHWAY: Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.

      SUBUNIT STRUCTURE: Homodimer.

      INDUCTION: Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).

      PTM: S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues.

      SEQUENCE SIMILARITIES: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
      Molecular Weight ~51 kDa observed. A band at ~100 kDa may be observed in some lysates and may be the homodimer of this protein.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in MCF-7 cell lysate.

      Western Blot Analysis: 10 µg/mL of this antibody detected ODC1 on 10 µg of MCF-7 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABS36 04053252414664

      Documentation

      Anti-ODC1 Antibody, clone CPTC-ODC1-2 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-ODC1 Antibody, clone CPTC-ODC1-2 Certificates of Analysis

      TitleLot Number
      Anti-ODC1, clone CPTC-ODC1-2 - 2432506 2432506
      Anti-ODC1, clone CPTC-ODC1-2 - 2364912 2364912
      Anti-ODC1, clone CPTC-ODC1-2 - 3221958 3221958
      Anti-ODC1, clone CPTC-ODC1-2 - 3288734 3288734
      Anti-ODC1, clone CPTC-ODC1-2 - 3388447 3388447
      Anti-ODC1, clone CPTC-ODC1-2 - 3521068 3521068
      Anti-ODC1, clone CPTC-ODC1-2 - NRG1832164 NRG1832164
      Anti-ODC1, clone CPTC-ODC1-2 -2689665 2689665
      Anti-ODC1, clone CPTC-ODC1-2 -2847006 2847006
      Anti-ODC1, clone CPTC-ODC1-2 -2860359 2860359
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