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09-466 Anti-phospho-CrkL (Tyr207) Antibody

Detect phospho-CrkL (Tyr207) using this Anti-phospho-CrkL (Tyr207) Antibody validated for use in WB.

Anti-phospho-CrkL (Tyr207) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Cytoskeletal Signaling Gene Symbol: v-crk avian sarcoma virus CT10 oncogene homolog-like, v-crk sarcoma virus CT10 oncogene homolog (avian)-like, Crk Like UniProt Number: P46109
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09-466
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, MWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number09-466
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-CrkL (Tyr207) Antibody
      Background InformationCRKL belongs to a family of adaptor proteins containing SH2/SH3 domains that couple to effector proteins including p130CAS, SOS, Abl, and Arg. CRKL plays a role in the mediation of Integrin- and Rac-dependent cell migration and in Ras-dependent activation of JNK. The protein is also involved in T-cell activation. Phosphorylation of CrkL on Tyr207 is known to be correlated with its inhibition.
      References
      Product Information
      FormatAffinity Purified
      Control
      • K562
      PresentationPurified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide in 50% glycerol.
      Quality LevelMQ100
      Applications
      ApplicationDetect phospho-CrkL (Tyr207) using this Anti-phospho-CrkL (Tyr207) Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH synthetic peptide including and encompassing Tyr 207 of human CrkL.
      HostRabbit
      SpecificityRecognizes CrkL only when phosphorylated on Tyr207.
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryNP_005198.1
      Gene Symbol
      • v-crk avian sarcoma virus CT10 oncogene homolog-like
      • v-crk sarcoma virus CT10 oncogene homolog (avian)-like
      • Crk Like
      Modifications
      • Phosphorylation
      UniProt Number
      UniProt SummaryFUNCTION: May mediate the transduction of intracellular signals.
      SIZE: 303 amino acids; 33777 Da
      SUBUNIT STRUCTURE:Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4.
      SIMILARITY: Contains 1 SH2 domain.Contains 2 SH3 domains.
      Molecular Weight39 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by western blot on K563 cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      09-466 04053252325779

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies