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852050 Fmoc-Trp(Boc)-OH

Fmoc-Trp(Boc)-OH Novabiochem®. CAS 143824-78-6, molar mass 526.59 g/mol.

Fmoc-Trp(Boc)-OH MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 143824-78-6 Molar Mass: 526.59 g/mol Hill Formula: C₃₁H₃₀N₂O₆
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852050
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Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
143824-78-6C₃₁H₃₀N₂O₆526.59 g/mol

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              8520501000
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                  Description
                  Catalogue Number852050
                  Replaces04-12-1103
                  Brand Family Novabiochem®
                  Alternate Names
                  • N-α-Fmoc-N-in-t.-Boc-L-tryptophan
                  Background InformationThe use of this N-in-Boc protected derivative overcomes most of the problems associated with the preparation of Trp containing-peptides by Fmoc SPPS [1]. Cleavage with TFA generates an N-in-carboxy indole which protects the Trp from alkylation [1, 2, 3] and sulfonation [1, 4, 5, 6, 7]. The N-in-carboxy group is removed under aqueous conditions during normal work-up of the peptide.



                  The product number for this product was previously 04-12-1103.

                  To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
                  References
                  Product Information
                  CAS number143824-78-6
                  Hill FormulaC₃₁H₃₀N₂O₆
                  Molar Mass526.59 g/mol
                  HS Code2933 99 49
                  Structure formula ImageStructure formula Image
                  Quality LevelMQ300
                  Applications
                  ApplicationFmoc-Trp(Boc)-OH Novabiochem®. CAS 143824-78-6, molar mass 526.59 g/mol.
                  Biological Information
                  Physicochemical Information
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  Storage class10 - 13 Other liquids and solids
                  WGKWGK 3 highly hazardous to water
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  StorageStore at -15°C to -25°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications
                  Color (visual)white to off white
                  Appearance of substance (visual)powder
                  Color index (0,5 M in DMF)≤ 150 Hazen
                  Identity (IR)passes test
                  Enantiomeric purity≥ 99.7 % (a/a)
                  Purity (HPLC)≥ 97.5 % (a/a)
                  Fmoc-ß-Ala-OH (HPLC)≤ 0.3 % (a/a)
                  Fmoc-ß-Ala-Trp (Boc)-OH (HPLC)≤ 0.1 % (a/a)
                  Fmoc-Trp(Boc)-Trp(Boc)-OH (HPLC)≤ 0.1 % (a/a)
                  Fmoc-Trp-OH (HPLC)≤ 1.0 % (a/a)
                  Assay free amino acid (HPLC)≤ 0.2 %
                  Solubility (25 mmole in 50 ml DMF)clear soluble
                  Purity (TLC(011A))≥ 98 %
                  Purity (TLC(0811))≥ 98 %
                  Assay (acidimetric)≥ 90.0 %
                  Water (K. F.)≤ 2.0 %
                  Ethyl acetate (HS-GC)≤ 2.5 %
                  Acetate (IC)≤ 0.10 %
                  For TLC-Systems see our General Catalog
                  Global Trade Item Number
                  Catalogue Number GTIN
                  8520500025 04027269087234
                  8520500100 04027269087241
                  8520500250 04027269207069
                  8520501000 04027269180461

                  Documentation

                  Fmoc-Trp(Boc)-OH SDS

                  Title

                  Safety Data Sheet (SDS) 

                  Citations

                  Title
                  • [1] P. White in 'Peptides, Chemistry & Biology, Proc. 12th American Peptide Symposium', J. A. Smith & J. E. Rivier (Eds), ESCOM, Leiden, 1992, pp. 537.
                  • [2] B. Riniker, et al. (1993) Tetrahedron, 49, 9307.
                  • [3] T. Johnson, et al. (1993) J. Chem. Soc., Chem. Commun., 369.
                  • [4] H. Choi, et al. (1993) Int. J. Peptide Protein Res., 42, 58.
                  • [5] C. G. Fields, et al. (1993) Tetrahedron Lett., 34, 6661.
                  • [6] T. Lescrinier, et al. (1995) Lett. Pept. Sci., 2, 225.
                  • [7] M. Noda & M. Kiffe (1997) J. Peptide Res., 50, 329.