Millipore Sigma Vibrant Logo

855059 Merrifield resin LL (100-200 mesh)

Novabiochem®

Merrifield resin LL (100-200 mesh) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 9003-70-7
View Products on Sigmaaldrich.com
855059
View Pricing & Availability

Overview

Replacement Information

Key Spec Table

CAS #
9003-70-7

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
8550590005
Retrieving availability...
—
Fulfillment and delivery delayed Fulfillment and delivery delayed
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Glass bottle 5 g
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      8550590025
      Retrieving availability...
      —
      Fulfillment and delivery delayed Fulfillment and delivery delayed
      In Stock 
      Discontinued
      Limited Quantities Available
      Availability to be confirmed
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          		 Plastic bottle 25 g
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity is a multiple of
          Maximum Quantity is
          Upon Order Completion More Information
          You Saved ()
           
          —
          Request Pricing
          		 —
          8550590100
          Retrieving availability...
          —
          Fulfillment and delivery delayed Fulfillment and delivery delayed
          In Stock 
          Discontinued
          Limited Quantities Available
          Availability to be confirmed
            Remaining : Will advise
              Remaining : Will advise
              Will advise
              Contact Customer Service
              Contact Customer Service

              		 Plastic bottle 100 g
              Retrieving price...
              Price could not be retrieved
              Minimum Quantity is a multiple of
              Maximum Quantity is
              Upon Order Completion More Information
              You Saved ()
               
              —
              Request Pricing
              		 —
              Description
              Catalogue Number855059
              Replaces01-64-0008
              Brand Family Novabiochem®
              Alternate Names
              • Chloromethylpolystyrene-divinylbenzene (100-200 mesh)
              Background InformationMerrifield resin was the standard support for the synthesis of peptide acids by Boc SPPS [1, 2]. In peptide chemistry, it is now really only used in the synthesis of small to medium sized peptides, as the benzylic ester resin linkage is not completely stable towards repetitive treatment with TFA.

              Attachment of the C-terminal residue is generally achieved by heating the resin in DMF with the appropriate amino acid cesium salt in the presence of KI [3]; although, Me4N salts [4], sodium salts [5] in THF with Bu4NF catalysis [6] and zinc salts in EtOH have also been used [7].

              Cleavage is normally effected by treatment of resin with HF or TFMSA, or by hydrogenolysis [8]. Alcohols can be released using reducing agents such as DIBAL [6] or LiBH4 [9]. Methyl esters can be produced by transesterification with methoxide [10].

              The product number for this product was previously 01-64-0008.

              To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
              References
              Product Information
              CAS number9003-70-7
              HS Code3903 90 90
              Structure formula ImageStructure formula Image
              Quality LevelMQ200
              Applications
              Biological Information
              Physicochemical Information
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Storage class10 - 13 Other liquids and solids
              WGKWGK 1 slightly hazardous to water
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              StorageStore below +30°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications
              Color (visual)white to yellow to beige
              Appearance of substance (visual)beads
              Loading (determined by elemental analysis for sulfur after derivatization with KSAc)0.40 - 1.10 mmol/g
              Swelling Volume (in CH₂Cl₂)lot specific result
              The polymer matrix is copoly (styrene-1 % DVB), 100 -200 mesh (75 - 150 µm)
              Global Trade Item Number
              Catalogue Number GTIN
              8550590005 04027269111816
              8550590025 04027269111823
              8550590100 04027269111830

              Documentation

              Merrifield resin LL (100-200 mesh) SDS

              Title

              Safety Data Sheet (SDS) 

              Citations

              Title
              • [1] M. Bodanszky, et al. in "Peptide Synthesis", E. Gross & J. Meienhofer (Eds), Academic Press, Y. Wiley, New York, 1976.
              • [2] G. Barany, et al. (1980) Peptides, 2, 1.
              • [3] B. F. Gisin (1973) Helv. Chim. Acta, 56, 1476.
              • [4] A. Loffet (1971) Int. J. Protein Res., 3, 297.
              • [5] S.-S. Wang (1975) J. Org. Chem., 40, 1235.
              • [6] M. J. Kurth, et al. (1994) J. Org. Chem., 59, 5862.
              • [7] M. V. Anuradha, et al. (1995) Tetrahedron, 51, 5671.
              • [8] J. M. Schlatter, et al. (1977) Tetrahedron Lett., 2851.
              • [9] J. M. Stewart, et al. (1981) , U.S. Patent 4,254,023.
              • [10] R. Frenette, et al. (1994) Proc. Natl. Acad. Sci. USA, 90, 6906.