Millipore Sigma Vibrant Logo

691400 Zebularine - CAS 3690-10-6 - Calbiochem

A cell-permeable chemically stable cytidine analog that displays antitumor properties.

Zebularine - CAS 3690-10-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside

Primary Target: Cytidine deaminase
View Products on Sigmaaldrich.com
691400
  
Retrieving price...
Price could not be retrieved
Minimum Quantity is a multiple of
Maximum Quantity is
Upon Order Completion More Information
You Saved ()
 
—
Request Pricing
—
Fulfillment and delivery delayed Fulfillment and delivery delayed
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

       

      Contact Customer Service

      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      3690-10-6C₉H₁₂N₂O₅
      Description
      OverviewA cell-permeable chemically stable cytidine analog that displays antitumor properties. Acts as transition state analog inhibitor of cytidine deaminase by binding at the active site as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.
      Catalogue Number691400
      Brand Family Calbiochem®
      Synonyms1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside
      References
      ReferencesCheng, J.C., et al. 2004. Cancer Cell 6, 151.
      Cheng, J.C., et al. 2003. J. Natl. Cancer Inst. 95, 399.
      Zhou, L., et al. 2002. J. Mol. Biol. 321, 591.
      Barchi, J.J., Jr., et al. 1992. J. Org. Chem. 57, 536.
      Frick, L., et al. 1989. Biochemistry 28, 9423.
      Product Information
      CAS number3690-10-6
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₉H₁₂N₂O₅
      Chemical formulaC₉H₁₂N₂O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCytidine deaminase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.


      From Catalog:
      Desc. Field- added "cell-permeable
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      691400 0

      Documentation

      Zebularine - CAS 3690-10-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Zebularine - CAS 3690-10-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      691400

      References

      Reference overview
      Cheng, J.C., et al. 2004. Cancer Cell 6, 151.
      Cheng, J.C., et al. 2003. J. Natl. Cancer Inst. 95, 399.
      Zhou, L., et al. 2002. J. Mol. Biol. 321, 591.
      Barchi, J.J., Jr., et al. 1992. J. Org. Chem. 57, 536.
      Frick, L., et al. 1989. Biochemistry 28, 9423.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-September-2008 RFH
      Synonyms1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside
      DescriptionA chemically stable, cytidine analog that displays anti-tumor properties. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number3690-10-6
      Chemical formulaC₉H₁₂N₂O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml) or Methanol (5 mg/ml). Slight warming may be required to achieve complete solubilization.
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.


      From Catalog:
      Desc. Field- added "cell-permeable
      Toxicity Standard Handling
      ReferencesCheng, J.C., et al. 2004. Cancer Cell 6, 151.
      Cheng, J.C., et al. 2003. J. Natl. Cancer Inst. 95, 399.
      Zhou, L., et al. 2002. J. Mol. Biol. 321, 591.
      Barchi, J.J., Jr., et al. 1992. J. Org. Chem. 57, 536.
      Frick, L., et al. 1989. Biochemistry 28, 9423.