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565780 β-Secretase Inhibitor III - Calbiochem

The β-Secretase Inhibitor III controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

β-Secretase Inhibitor III - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Inhibitor GL189, H-EVNstatineVAEF-NH₂

Primary Target: BACE
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565780
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Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₄₄H₇₀N₁₀O₁₄

Prix & Disponibilité

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565780-500UG
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      		 Ampoule plast. 500 μg
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      Description
      OverviewA substrate analog inhibitor of β-secretase (BACE) that completely blocks the proteolytic activity (at 5 µM) in solubilized membrane fractions from BACE transfected MDCK cells.
      Catalogue Number565780
      Brand Family Calbiochem®
      SynonymsInhibitor GL189, H-EVNstatineVAEF-NH₂
      References
      ReferencesCapell, A., et al. 2002. J. Biol. Chem. 277, 5637.
      Tung, J.S., et al. 2002. J. Med. Chem. 45, 259.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₄₄H₇₀N₁₀O₁₄
      Chemical formulaC₄₄H₇₀N₁₀O₁₄
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetBACE
      Primary Target IC<sub>50</sub>Effective concentration: 5 µM completely blocking the proteolytic activity of β-secretase (BACE) in solubilized membrane fractions from BACE transfected MDCK cells
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Glu-Val-Asn-Statine-Val-Ala-Glu-Phe-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      565780-500UG 04055977267280

      Documentation

      β-Secretase Inhibitor III - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      β-Secretase Inhibitor III - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      565780

      Références bibliographiques

      Aperçu de la référence bibliographique
      Capell, A., et al. 2002. J. Biol. Chem. 277, 5637.
      Tung, J.S., et al. 2002. J. Med. Chem. 45, 259.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-September-2008 RFH
      SynonymsInhibitor GL189, H-EVNstatineVAEF-NH₂
      DescriptionA substrate analog inhibitor of β-secretase (BACE) that completely blocks proteolytic activity in solubilized membrane fractions of BACE-transfected MDCK cells at a concentration of 5 µM.
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₄₄H₇₀N₁₀O₁₄
      Peptide SequenceH-Glu-Val-Asn-Statine-Val-Ala-Glu-Phe-NH₂
      Purity≥95% by HPLC
      SolubilityDMSO (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesCapell, A., et al. 2002. J. Biol. Chem. 277, 5637.
      Tung, J.S., et al. 2002. J. Med. Chem. 45, 259.