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287815 3,4-Dichloroisocoumarin - CAS 51050-59-0 - Calbiochem

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Primary Target: serine proteases
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287815
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
51050-59-0C₉H₄Cl₂O₂

Prix & Disponibilité

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287815-10MG
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      		 Ampoule plast. 10 mg
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      Description
      OverviewA potent, irreversible inhibitor of serine proteases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Inhibits granzyme B and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Does not affect thiol proteases and metalloproteases. Does not exhibit any activity towards β-lactamases.
      Effective concentration: 5-100 µM; t½ = 20 min at pH 7.5.
      Catalogue Number287815
      Brand Family Calbiochem®
      References
      ReferencesCain, K., et al. 1994. Biochem. Cell Biol. 72, 631.
      Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
      Odake, S., et al. 1991. Biochemistry 30, 2217.
      Harper, J.W., et al. 1985. Biochemistry 24, 1831.
      Product Information
      CAS number51050-59-0
      ATP CompetitiveN
      FormWhite lyophilized solid
      Hill FormulaC₉H₄Cl₂O₂
      Chemical formulaC₉H₄Cl₂O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetserine proteases
      Primary Target IC<sub>50</sub>5-100 µM
      Purity≥99% by elemental analysis
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      287815-10MG 04055977197860

      Documentation

      3,4-Dichloroisocoumarin - CAS 51050-59-0 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      3,4-Dichloroisocoumarin - CAS 51050-59-0 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      287815

      Références bibliographiques

      Aperçu de la référence bibliographique
      Cain, K., et al. 1994. Biochem. Cell Biol. 72, 631.
      Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
      Odake, S., et al. 1991. Biochemistry 30, 2217.
      Harper, J.W., et al. 1985. Biochemistry 24, 1831.

      Brochure

      Titre
      Caspases and other Apoptosis Related Tools Brochure

      Citations

      Titre
    • Dong Zhang, et al. (2001) Granzymes A and B Directly Cleave Lamins and Disrupt the Nuclear Lamina During Granule-Mediated Cytolysis. Proceedings of the National Academy of Science USA 98, 5746-5751.
      		•
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-June-2008 RFH
      DescriptionA potent irreversible inhibitor of serine proteases. Blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Does not affect thiol proteases and metalloproteases. Also has no activity towards β-lactamases. Effective at concentrations ranging from 5-100 µM.
      FormWhite lyophilized solid
      CAS number51050-59-0
      Chemical formulaC₉H₄Cl₂O₂
      Structure formulaStructure formula
      Purity≥99% by elemental analysis
      SolubilityDMF (10 mM) or DMSO (10 mM)
      Storage Protect from moisture
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesCain, K., et al. 1994. Biochem. Cell Biol. 72, 631.
      Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
      Odake, S., et al. 1991. Biochemistry 30, 2217.
      Harper, J.W., et al. 1985. Biochemistry 24, 1831.
      Citation
    • Dong Zhang, et al. (2001) Granzymes A and B Directly Cleave Lamins and Disrupt the Nuclear Lamina During Granule-Mediated Cytolysis. Proceedings of the National Academy of Science USA 98, 5746-5751.
      		•