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ABS983 Anti-DMT1 Antibody

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ABS983
100 µL  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, ICCRbSerumPolyclonal Antibody
      Description
      Catalogue NumberABS983
      DescriptionAnti-DMT1 Antibody
      Alternate Names
      • NRAM1
      • NRAMP 2
      • NRAMP-2
      • Divalent metal transporter 1
      • Divalent cation transporter 1
      • DMT-1
      Background InformationDivalent metal ion transporter 1 (DMT1) is a proton-coupled Fe2+ transporter that is essential for iron uptake in enterocytes and for transferrin-associated endosomal iron transport in many other cell types. DMT1 dysfunction is associated with several diseases such as iron overload disorders and neurodegenerative diseases. DMT1 can transport manganese, cobalt, cadmium, nickel, and vanadium. DMT1 is also involved in iron transport from acidified endosomes into the cytoplasm in erythroid precursor cells as well as liver internal metabolism of iron. Interestingly too, in mammalian cells, mitochondria receive most incoming iron, and the outer mitochondrial membrane appears to be a major location for DMT1, which appears to be the major importer of iron into the mitochondria.
      References
      Product Information
      FormatSerum
      PresentationRabbit polyclonal serum with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-DMT1 Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of DMT1.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesWestern Blot Analysis: 2 µg/ml of this antibody detected DMT1 in 50 µg of mouse liver, spleen and duodenum tissue lysate (Schumann, K.,et al. (2010). Journal of Trace Elements in Medicine and Biology 24 (2010) 58–66)
      Immunocytochemistry Analysis: A 1:100 dilution of this antibody from a representative lot detected DMT1 in Hela, A431, and N1H-3T3 cells
      Biological Information
      ImmunogenRecombinant protein corresponding to human DMT1.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SLC11A2
      • DCT1
      • DMT1
      • NRAMP2
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~ 62 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human placenta tissue lysate.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected DMT1 in 10 µg of human placenta tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      ABS983 04055977052169

      Documentation

      Anti-DMT1 Antibody FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-DMT1 Antibody Certificats d'analyse

      TitreNuméro de lot
      Anti-DMT1 - Q2464801 Q2464801
      Anti-DMT1 - 3051527 3051527
      Anti-DMT1 - 3823693 3823693
      Anti-DMT1 - 3951355 3951355
      Anti-DMT1 -2686123 2686123
      Anti-DMT1 Polyclonal Antibody 2900045
      Anti-DMT1 Polyclonal Antibody 2870417

      Références bibliographiques

      Aperçu de la référence bibliographiqueNº PubMed
      Iron absorption and distribution in TNF(DeltaARE/+) mice, a model of chronic inflammation.
      Schümann, Klaus, et al.
      J Trace Elem Med Biol, 24: 58-66 (2010)  2009

      Afficher le résumé
      20122582 20122582