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MABN238 Anti-Glucagon Antibody, clone 13D11.33

Detect Glucagon using this Anti-Glucagon Antibody, clone 13D11.33 validated for use in IHC(P), Immunofluorescence, ELISA, Multiplexing.

Anti-Glucagon Antibody, clone 13D11.33 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Neuroscience Research Sub-Category: Sensory & PNS Gene Symbol: GCG UniProt Number: P01275
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MABN238
100 µg  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RIH(P), IF, ELISA, MplexMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN238
      DescriptionAnti-Glucagon Antibody, clone 13D11.33
      Alternate Names
      • 4030-01F
      • 4031-01F
      • AB932
      Background InformationGlucagon is a hormone that is proteolytically cleaved into at least eight different functional peptides. It is produced by pancreatic cells and it has binding sites in the brain, intestines, and liver, among other tissues. Glucagon is secreted in response to hypoglycemia. Through the combined activation of Gsα- and Gq-coupled transmembrane receptors and their downstream signaling pathways, glucagon stimulates the release of glucose from the liver into the bloodstream. One important mechanism underlying this process is the activation of protein kinase A (PKA). PKA signals result in increased transcription of phosphoenolpyruvate carboxykinase, which encodes the rate-limiting enzyme in the production of glucose from noncarbohydrate substrates. PKA signals may also increase the breakdown of glycogen, and suppress glycolysis. Glucagon may also engage in calcium-dependent signaling via PLC. The importance of glucagon in regulating glucose homeostasis, in conjunction with insulin, is underscored by findings that glucagon and glucagon receptor signaling are disrupted in type II diabetes.
      References
      Product Information
      FormatPurified
      Control
      • Normal rat pancreas tissue
      PresentationPurified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Glucagon using this Anti-Glucagon Antibody, clone 13D11.33 validated for use in IHC(P), Immunofluorescence, ELISA, Multiplexing.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Immunofluorescence
      • ELISA
      • Multiplexing
      Application NotesImmunohistochemistry Analysis: A 1:8,000 dilution from a representative lot detected Glucagon in normal rat pancreas tissue (For enhanced staining results, it is recommended to use a 10,000 dilution of this antibody.).

      ELISA Analysis: A representative lot detected Glucagon in ELISA.

      Luminex® Analysis: A representative lot detected Glucagon in Luminex Assay.
      Biological Information
      ImmunogenOvalbumin-conjugated linear peptide corresponding to human Glucagon.
      Clone13D11.33
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • GCG
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight21 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunofluorescence in normal rat pancreas tissue.

      Immunofluorescence Analysis: A 1:8,000 dilution of this antibody detected Glucagon in normal rat pancreas tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MABN238 04053252691966

      Documentation

      Anti-Glucagon Antibody, clone 13D11.33 FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-Glucagon Antibody, clone 13D11.33 Certificats d'analyse

      TitreNuméro de lot
      Anti-Glucagon, clone 13D11.33 - 2424845 2424845
      Anti-Glucagon, clone 13D11.33 - 2427501 2427501
      Anti-Glucagon, clone 13D11.33 - 2438690 2438690
      Anti-Glucagon, clone 13D11.33 - 2208803 2208803
      Anti-Glucagon, clone 13D11.33 - 2315723 2315723
      Anti-Glucagon, clone 13D11.33 - 2341101 2341101
      Anti-Glucagon, clone 13D11.33 - 3488907 3488907
      Anti-Glucagon, clone 13D11.33 - 3817615 3817615
      Anti-Glucagon, clone 13D11.33 - 4004380 4004380
      Anti-Glucagon, clone 13D11.33 - 4005710 4005710
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      Catégories

      Life Science Research > Antibodies and Assays > Primary Antibodies