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ABC248 Anti-HPGD Antibody

Detect Prostaglandin dehydrogenase 1 using this rabbit polyclonal antibody, Anti-HPGD Antibody validated for use in western blotting & IHC.

Anti-HPGD Antibody : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: HPGD, PGDH1 UniProt Number: P15428
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ABC248
100 µg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC248
      DescriptionAnti-HPGD Antibody
      Alternate Names
      • 15-hydroxyprostaglandin dehydrogenase [NAD(+)]
      • Prostaglandin dehydrogenase 1
      • 15-PGDH
      Background InformationThe protein named HPGD, or also known as 15-PGDH, or Prostaglandin dehydrogenase 1, and encoded by the gene HPGD/PGDH1, is a protein necessary for the regulation of prostaglandin levels. Prostaglandins are potent inflammatory agents, thus their regulation is key for control inflammatory responses. HPGD works to mediate prostaglandin inactivation by catalyzing the NAD dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoin A4. Additionally, HPGD inhibits in vivo proliferation of colon cancer cells. HPGD is localized to the cytoplasm. HPGD is expressed in intestinal and colon tissues. HPGD is down regulated in colon cancer and thus is being examined as a therapeutic agent. Defects in HPGD may be associated with Hypertrophic osteoarthropathy, a disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. Other diseases associated with this gene’s defects are Crainoosteoarthropathy (swollen joint disease) and congenital nail clubbing where one has very large nails on the fingers and toes.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit Polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Prostaglandin dehydrogenase 1 using this rabbit polyclonal antibody, Anti-HPGD Antibody validated for use in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:500 dilution from a representative lot detected HPGD in human ileum tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human HPGD.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Primate, Chimpanzee, Monkey, Baboon, and Rabbit based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HPGD
      • PGDH1
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~32 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Caco-2 cell lysate.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected HPGD in 10 µg of Caco-2 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      ABC248 04053252937408