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MABC287 Anti-PXR Antibody, clone 1F10.1

Detect PXR using this Anti-PXR Antibody, clone 1F10.1 validated for use in Western Blotting.

Anti-PXR Antibody, clone 1F10.1 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: NR1I2, PXR UniProt Number: O75469
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MABC287
100 μg  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC287
      DescriptionAnti-PXR Antibody, clone 1F10.1
      Alternate Names
      • Nuclear receptor subfamily 1 group I member 2
      • Orphan nuclear receptor PAR1
      • Orphan nuclear receptor PXR
      • Pregnane X receptor
      • Steroid and xenobiotic receptor
      • SXR
      • PXR
      Background InformationNuclear receptor subfamily 1 group I member 2 (UniProt O75469; also known as Orphan nuclear receptor PAR1, Orphan nuclear receptor PXR, Pregnane X nuclear receptor, Steroid and xenobiotic receptor, SXR) is encoded by the NR1I2 (also known as BXR, PAR, PRR, PXR, SAR, SXR, ONR1) gene (Gene ID 8856) in human. Pregnane X receptor (PXR) is a nuclear receptor that displays similarity to PPAR and RXR. PXR is activated by a large number of endogenous and exogenous chemicals including steroids and antibiotics. One of the key roles of PXR is the induction of CYP3A4, a P450 enzyme involved in drug metabolism.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect PXR using this Anti-PXR Antibody, clone 1F10.1 validated for use in Western Blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected PXR in 10 µg of human liver tissue lysate.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human PXR.
      Clone1F10.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityEpitope is present in all 7 alternative spliced isoforms (isoform 1A/PRR1-A, 1B/PRR1-B, 1C/PRR1-C, 2A/PRR2-A, 2B/PRR2-V, 2C/PRR2-C, and isoform 3).
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Chimpanzee, Gorilla based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NR1I2
      • PXR
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~53 kDa observed. Uniprot describes 7 isoforms produced by alternative splicing ranging from ~40 kDa-54 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human colon tissue lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected PXR in 10 µg of human colon tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MABC287 04055977173154

      Documentation

      Anti-PXR Antibody, clone 1F10.1 FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-PXR Antibody, clone 1F10.1 Certificats d'analyse

      TitreNuméro de lot
      Anti-PXR, clone 1F10.1 - 3703585 3703585
      Anti-PXR, clone 1F10.1 - 4048030 4048030
      Anti-PXR, clone 1F10.1 -Q2573229 Q2573229

      Informations techniques

      Titre
      Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
      White Paper: Further considerations of antibody validation and usage.