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SCT076 BioTracker Red Hydrogen Sulphide Live Cell Dye

Live cell imaging probe for hydrogen sulphide, a gaseous signaling molecule. Exhibits red fluorescence in presence of H2S.

SCT076
1 mg  
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      Aperçu

      Replacement Information
      Description
      Catalogue NumberSCT076
      DescriptionBioTracker Red Hydrogen Sulphide Live Cell Dye
      OverviewHydrogen silfide (H2S) has emerged as an important gaseous signaling molecule and important physiological mediator in living organisms. The endogenous H2S is mainly produced in mitochondria or cytosol by enzymatic reactions, where it regulates energy production in mitochondria under stressful conditions. In addition, H2S appears to be involved in various physiological processes, such as suppression of oxidative stress, modulation of neurotransmission, calcium homeostasis, and long-term potentiation. Abnornal concentrations of H2S have been correlated with CNS diseases such as Down syndrome, Alzheimer's disease, and other diseases of mental deficiency.

      BioTracker Blue Hydrogen sulfide live cell dye (SCT075) and BioTracker Red Hydrogen sulfide live cell dye (SCT076) are selenosulfides
      tethered to gem-dimethyl esters, which act as excellent framework for H2S probe development. SCT075 and SCT076 were tested with HeLa cells and HEK293 cells. When stimulated with Na2S, these cells produced H2S, which was detected using these probes.

      Spectral Properties
      Excitation: 561 nm
      Emission: 587 nm (Red)

      References:
      Suarez S.I., et al. Selenosulfides Tethered to Gem-Dimethyl Esters: A Robust and Highly Versatile Framework for H2S Probe Development. Chem. Eur. J. 2019, 25, 15736-15740.
      Alternate Names
      • Live cell imaging probe
      References
      Product Information
      Detection methodFluorescence
      PresentationLyophilized
      Applications
      ApplicationLive cell imaging probe for hydrogen sulphide, a gaseous signaling molecule. Exhibits red fluorescence in presence of H2S.
      Key Applications
      • Cell Based Assays
      Application NotesLive cell fluorescent imaging
      Biological Information
      Molecular Weight493.43
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssurancePurity: ≥ 97% confirmed by HNMR, LC-MS and HPLC and elemental analysis
      Molar Mass: 442.39 g/mol
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore BioTracker Red Hydrogen Sulphide Live Cell Dye at -20°C, desiccate and protect from light
      Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      SCT076 04061842297528