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218750 Caspase-3 Inhibitor III - CAS 285570-60-7 - Calbiochem

The Caspase-3 Inhibitor III, also referenced under CAS 285570-60-7, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Ac-DEVD-CMK

Primary Target: caspase-3, caspase-6, caspase-7, caspase-8, caspase-10
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      285570-60-7C₂₁H₃₁ClN₄O₁₁
      Description
      OverviewA potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10.
      Catalogue Number218750
      Brand Family Calbiochem®
      SynonymsAc-DEVD-CMK
      References
      ReferencesMocanu, M.M., et al. 2000. Br. J. Pharmacol. 130, 197
      Schrantz, N., et al. 1999. Cell Death Differ. 6, 445.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Product Information
      CAS number285570-60-7
      ATP CompetitiveN
      FormWhite to off-white lyophilized solid or powder
      Hill FormulaC₂₁H₃₁ClN₄O₁₁
      Chemical formulaC₂₁H₃₁ClN₄O₁₁
      HS Code2924 19 99
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcaspase-3, caspase-6, caspase-7, caspase-8, caspase-10
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceAc-Asp-Glu-Val-Asp-CMK
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      218750 0

      Documentation

      Caspase-3 Inhibitor III - CAS 285570-60-7 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Caspase-3 Inhibitor III - CAS 285570-60-7 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      218750

      Références bibliographiques

      Aperçu de la référence bibliographique
      Mocanu, M.M., et al. 2000. Br. J. Pharmacol. 130, 197
      Schrantz, N., et al. 1999. Cell Death Differ. 6, 445.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

      Brochure

      Titre
      Caspases and other Apoptosis Related Tools Brochure

      Citations

      Titre
    • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.
      		•
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-April-2018 JSW
      SynonymsAc-DEVD-CMK
      DescriptionA potent cell-permeable and irreversible inhibitor of caspase-3, a member of the ICE-CED-3 family of cysteine proteases.
      FormWhite to off-white lyophilized solid or powder
      CAS number285570-60-7
      Chemical formulaC₂₁H₃₁ClN₄O₁₁
      Peptide SequenceAc-Asp-Glu-Val-Asp-CMK
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Solubility20% Acetonitrile (in H₂O) (1 mg/ml)
      Storage Protect from moisture
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Toxicity Standard Handling
      ReferencesMocanu, M.M., et al. 2000. Br. J. Pharmacol. 130, 197
      Schrantz, N., et al. 1999. Cell Death Differ. 6, 445.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Citation
    • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.
      		•