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364205 GM 6001 - CAS 142880-36-2 - Calbiochem

GM 6001, CAS 142880-36-2, is a potent, cell-permeable, broad-spectrum inhibitor of MMPs (Ki = 400 pM for MMP-1; 500 pM for MMP-2; 27 nM for MMP-3; 100 pM for MMP-8; and 200 pM for MMP-9).

GM 6001 - CAS 142880-36-2 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Galardin, N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan Methylamide

Primary Target: MMP-1
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      142880-36-2C₂₀H₂₈N₄O₄
      Description
      OverviewA potent, cell-permeable, broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs); (Ki = 400 pM for MMP-1; Ki = 500 pM for MMP-2; Ki = 27 nM for MMP-3; Ki = 100 pM for MMP-8; and Ki = 200 pM for MMP-9). Prevents the release of TNF-α in vivo and in vitro and abrogates endotoxin-induced lethality in mice. A 10 mM (1 mg/257 µl) solution of GM6001 (Cat. No. 364206) in DMSO is also available.
      Catalogue Number364205
      Brand Family Calbiochem®
      SynonymsGalardin, N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan Methylamide
      References
      ReferencesSolorzano, C.C., et al. 1997. Shock 7, 427.
      Galardy, R.E., et al. 1994. Ann. NY Acad. Sci. 732, 315.
      Galardy, R.E., et al. 1994. Cancer Res. 54, 4715.
      Galardy, R.E. 1993. Drugs Future 18, 1109.
      Grobelny, D., et al. 1992. Biochemistry 31, 7152.
      Product Information
      CAS number142880-36-2
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₀H₂₈N₄O₄
      Chemical formulaC₂₀H₂₈N₄O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationGM 6001, CAS 142880-36-2, is a potent, cell-permeable, broad-spectrum inhibitor of MMPs (Ki = 400 pM for MMP-1; 500 pM for MMP-2; 27 nM for MMP-3; 100 pM for MMP-8; and 200 pM for MMP-9).
      Biological Information
      Primary TargetMMP-1
      Primary Target K<sub>i</sub>400 pM for MMP-1; 500 pM for MMP-2; 27 nM for MMP-3; 100 pM for MMP-8; 200 pM for MMP-9
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      364205 0

      Documentation

      GM 6001 - CAS 142880-36-2 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      GM 6001 - CAS 142880-36-2 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      364205

      Références bibliographiques

      Aperçu de la référence bibliographique
      Solorzano, C.C., et al. 1997. Shock 7, 427.
      Galardy, R.E., et al. 1994. Ann. NY Acad. Sci. 732, 315.
      Galardy, R.E., et al. 1994. Cancer Res. 54, 4715.
      Galardy, R.E. 1993. Drugs Future 18, 1109.
      Grobelny, D., et al. 1992. Biochemistry 31, 7152.

      Citations

      Titre
    • K. Fredriksson, et al. (2006) Red blood cells increase secretion of matrix metalloproteinases from human lung fibroblasts in vitro. American Journal of Physiology Lung Cellular and Molecular Physiology 290, L326-L333.
    • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
    • IM, E., et al. 2005. Molecular Biology of the Cell 16, 3488.
    • Daniel W. Lambert, et al. (2005) Tumor Necrosis Factor- Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2). Journal of Biological Chemistry 280, 30113-30119.
    • Haili Su, et al. (2005) Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation 112, 3157-3167.
      		•
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2008 RFH
      SynonymsGalardin, N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan Methylamide
      DescriptionA cell-permeable, potent broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs). [Ki = 0.4 nM for skin fibroblast collagenase (MMP-1); Ki = 0.5 nM for gelatinase A (MMP-2); Ki = 27 nM for stromelysin (MMP-3); Ki = 0.1 nM for neutrophil collagenase (MMP-8); and Ki = 0.2 nM for gelatinase B (MMP-9)]. Also prevents the release of TNF-α in vivo and in vitro and abrogates endotoxin-induced lethality in mice.
      FormOff-white solid
      CAS number142880-36-2
      Chemical formulaC₂₀H₂₈N₄O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesSolorzano, C.C., et al. 1997. Shock 7, 427.
      Galardy, R.E., et al. 1994. Ann. NY Acad. Sci. 732, 315.
      Galardy, R.E., et al. 1994. Cancer Res. 54, 4715.
      Galardy, R.E. 1993. Drugs Future 18, 1109.
      Grobelny, D., et al. 1992. Biochemistry 31, 7152.
      Citation
    • K. Fredriksson, et al. (2006) Red blood cells increase secretion of matrix metalloproteinases from human lung fibroblasts in vitro. American Journal of Physiology Lung Cellular and Molecular Physiology 290, L326-L333.
    • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
    • IM, E., et al. 2005. Molecular Biology of the Cell 16, 3488.
    • Daniel W. Lambert, et al. (2005) Tumor Necrosis Factor- Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2). Journal of Biological Chemistry 280, 30113-30119.
    • Haili Su, et al. (2005) Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation 112, 3157-3167.
      		•