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551476 InSolution™ Q-VD-OPh, Non-O-methylated - Calbiochem

InSolution™ Q-VD-OPh, Non-O-methylated, is a cell-permeable, irreversible, broad-spectrum inhibitor of caspases (IC₅₀ = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone

Primary Target: caspase-1
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula
      C₂₆H₂₅F₂N₃O₆
      Description
      OverviewA cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC50 = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.
      Catalogue Number551476
      Brand Family Calbiochem®
      SynonymsN-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone
      References
      ReferencesBraun, J.S., et al. 2007. Exp. Neurol. 206, 183.
      Caserta, T.M., et al. 2003. Apoptosis 8, 345.
      Rebbaa, A., et al. 2003. Oncogene 22, 2805.
      Product Information
      ATP CompetitiveN
      FormLiquid
      FormulationSupplied as a 10 mM (1 mg/195 µl) solution in DMSO.
      Hill FormulaC₂₆H₂₅F₂N₃O₆
      Chemical formulaC₂₆H₂₅F₂N₃O₆
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcaspase-1
      Primary Target IC<sub>50</sub>50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceQ-Val-Asp-CH₂-OPh
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      551476 0

      Documentation

      InSolution™ Q-VD-OPh, Non-O-methylated - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      InSolution™ Q-VD-OPh, Non-O-methylated - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      551476

      Références bibliographiques

      Aperçu de la référence bibliographique
      Braun, J.S., et al. 2007. Exp. Neurol. 206, 183.
      Caserta, T.M., et al. 2003. Apoptosis 8, 345.
      Rebbaa, A., et al. 2003. Oncogene 22, 2805.

      Brochure

      Titre
      Caspases and other Apoptosis Related Tools Brochure

      Citations

      Titre
    • Braun, J.S., et al. 2007. Exp. Neurol. 206, 183.
    • Jessica H. Dworet and Judy L. Meinkoth. 2006.Molecular Endocrinology 20, 1112.
    • Ademi E. Santiago-Walker, et al. (2005) Protein Kinase C δ Stimulates Apoptosis by Initiating G1 Phase Cell Cycle Progression and S Phase Arrest. Journal of Biological Chemistry 280, 32107-32114.
      		•
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-February-2012 RFH
      SynonymsN-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone
      DescriptionA cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC50 = 50 nM for caspase-1; IC50 = 100 nM for caspase-8; IC50 = 430 nM for caspase-9; IC50 < 25 nM for caspase-3). Exhibits effective anti-apoptotic properties against all major caspase-mediated cellular apoptosis pathways, including caspase 9/3, caspase 8/10, and caspase 12. Does not exhibit toxic effects even at high concentrations. To reduce hydrophobicity of the peptide and facilitate its use in aqueous media the aspartyl residue is not O-methylated. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.
      FormLiquid
      FormulationSupplied as a 10 mM (1 mg/195 µl) solution in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₆H₂₅F₂N₃O₆
      Peptide SequenceQ-Val-Asp-CH₂-OPh
      Structure formulaStructure formula
      Purity≥90% by HPLC
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesBraun, J.S., et al. 2007. Exp. Neurol. 206, 183.
      Caserta, T.M., et al. 2003. Apoptosis 8, 345.
      Rebbaa, A., et al. 2003. Oncogene 22, 2805.
      Citation
    • Braun, J.S., et al. 2007. Exp. Neurol. 206, 183.
    • Jessica H. Dworet and Judy L. Meinkoth. 2006.Molecular Endocrinology 20, 1112.
    • Ademi E. Santiago-Walker, et al. (2005) Protein Kinase C δ Stimulates Apoptosis by Initiating G1 Phase Cell Cycle Progression and S Phase Arrest. Journal of Biological Chemistry 280, 32107-32114.
      		•