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487960 Nociceptin - CAS 170713-75-4 - Calbiochem

Endogenous ligand for the opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1).

Nociceptin - CAS 170713-75-4 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Orphanin FQ, OFQ, NC, FGGFTGARKSARKLANQ

Primary Target: Opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1)
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487960
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
170713-75-4C₇₉H₁₂₉N₂₇O₂₂

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      Description
      OverviewEndogenous ligand for the opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1). Has no significant activity on the µ, δ, or κ opioid receptors; however, nanomolar concentrations of nociceptin inhibit forskolin-stimulated adenylyl cyclase activity in cells transfected with the G-protein coupled receptor LC132, which is similar in sequence to the opioid receptor. Also reported to cause hypertension and bradycardia in mice.
      Catalogue Number487960
      Brand Family Calbiochem®
      SynonymsOrphanin FQ, OFQ, NC, FGGFTGARKSARKLANQ
      References
      ReferencesMadeddu, P., et al. 1999. Hypertension 33, 914.
      Sandin, J., et al. 1999. NeuroReport 10, 71.
      Meunier, J., et al. 1995. Nature 377, 532.
      Reinscheid, R.K., et al. 1995. Science 270, 792.
      Product Information
      CAS number170713-75-4
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₇₉H₁₂₉N₂₇O₂₂
      Chemical formulaC₇₉H₁₂₉N₂₇O₂₂
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetOpioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1)
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      487960-1MG 04055977200447

      Documentation

      Nociceptin - CAS 170713-75-4 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Nociceptin - CAS 170713-75-4 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      487960

      Références bibliographiques

      Aperçu de la référence bibliographique
      Madeddu, P., et al. 1999. Hypertension 33, 914.
      Sandin, J., et al. 1999. NeuroReport 10, 71.
      Meunier, J., et al. 1995. Nature 377, 532.
      Reinscheid, R.K., et al. 1995. Science 270, 792.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-August-2008 RFH
      SynonymsOrphanin FQ, OFQ, NC, FGGFTGARKSARKLANQ
      DescriptionEndogenous ligand for the opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1). Has no significant activity at the µ, δ, or κ opioid receptors; however, nanomolar concentrations of Nociceptin inhibit, forskolin-stimulated adenylyl cyclase activity in cells transfected with the G-protein coupled receptor LC132, which is similar in sequence to the opioid receptor. Also reported to cause hypertension and bradycardia in mice.
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      CAS number170713-75-4
      Chemical formulaC₇₉H₁₂₉N₂₇O₂₂
      Peptide SequenceH-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH
      Purity≥98% by HPLC
      SolubilityH₂O (10 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
      Toxicity Standard Handling
      ReferencesMadeddu, P., et al. 1999. Hypertension 33, 914.
      Sandin, J., et al. 1999. NeuroReport 10, 71.
      Meunier, J., et al. 1995. Nature 377, 532.
      Reinscheid, R.K., et al. 1995. Science 270, 792.