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567021 Simvastatin, Sodium Salt - Calbiochem

Simvastatin, Sodium Salt is a carboxylate form of Simvastatin. Active in whole cells and in cell-free preparations. An inhibitor of HMG-CoA reductase.

Simvastatin, Sodium Salt - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: L-Type Calcium Channel Blocker VI

Primary Target: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula
      C₂₅H₃₉O₆ • Na
      Description
      OverviewCarboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free preparations. Also available as a 10 mM solution in H2O (Cat. No. 567022).
      Catalogue Number567021
      Brand Family Calbiochem®
      SynonymsL-Type Calcium Channel Blocker VI
      References
      ReferencesYada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
      Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
      Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
      Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
      Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
      Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
      Product Information
      ATP CompetitiveN
      FormBeige solid
      Hill FormulaC₂₅H₃₉O₆ • Na
      Chemical formulaC₂₅H₃₉O₆ • Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      567021 0

      Documentation

      Simvastatin, Sodium Salt - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      567021

      Références bibliographiques

      Aperçu de la référence bibliographique
      Yada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
      Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
      Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
      Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
      Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
      Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-October-2015 JSW
      SynonymsL-Type Calcium Channel Blocker VI
      DescriptionCarboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: This product is supplied in an active form; no treatment with NaOH in ethanol is required for its activation.
      FormBeige solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₅H₃₉O₆ • Na
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml), Ethanol (25 mg/ml), or H₂O (5 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesYada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
      Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
      Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
      Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
      Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
      Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.