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566660 Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem

A cell-permeable Smoothened Agonist, SAG, CAS 364590-63-6, modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N-Methyl-Nʹ-(3-pyridinylbenzyl)-Nʹ-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, SAG1.3

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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      364590-63-6C₂₈H₂₈ClN₃OS • 2HCl • 2H₂O
      Description
      OverviewA cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Smo internalization. Shown to induce Hedgehog pathway activation (EC50 = ∼ 3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations. A 10 mM (500 µg/86 µl) solution of Smoothened Agonist, SAG (Cat. No. 566661) in H2O is also available.
      Catalogue Number566660
      Brand Family Calbiochem®
      SynonymsN-Methyl-Nʹ-(3-pyridinylbenzyl)-Nʹ-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, SAG1.3
      References
      ReferencesWang, J., et al. 2010. Proc. Natl. Acad. Sci. USA. 107, 9323.
      Meloni, A.R., et al. 2006. Mol. Cell. Biol. 26, 7750.
      Chen, W., et al. 2004. Science 306, 2257.
      Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
      Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
      Product Information
      CAS number364590-63-6
      FormLight yellow solid
      Hill FormulaC₂₈H₂₈ClN₃OS • 2HCl • 2H₂O
      Chemical formulaC₂₈H₂₈ClN₃OS • 2HCl • 2H₂O
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      566660 0

      Documentation

      Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      566660

      Références bibliographiques

      Aperçu de la référence bibliographique
      Wang, J., et al. 2010. Proc. Natl. Acad. Sci. USA. 107, 9323.
      Meloni, A.R., et al. 2006. Mol. Cell. Biol. 26, 7750.
      Chen, W., et al. 2004. Science 306, 2257.
      Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
      Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.

      Citations

      Titre
    • Wang, J., et al. 2010. Proc. Natl. Acad. Sci. USA. 107, 9323.
      		•
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-February-2012 RFH
      SynonymsN-Methyl-Nʹ-(3-pyridinylbenzyl)-Nʹ-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, SAG1.3
      DescriptionA cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Smo internalization. Shown to induce Hedgehog pathway activation (EC50 ∼3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations.
      FormLight yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number364590-63-6
      Chemical formulaC₂₈H₂₈ClN₃OS • 2HCl • 2H₂O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml) or H₂O (25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesWang, J., et al. 2010. Proc. Natl. Acad. Sci. USA. 107, 9323.
      Meloni, A.R., et al. 2006. Mol. Cell. Biol. 26, 7750.
      Chen, W., et al. 2004. Science 306, 2257.
      Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
      Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
      Citation
    • Wang, J., et al. 2010. Proc. Natl. Acad. Sci. USA. 107, 9323.
      		•