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567540 Sodium Orthovanadate - CAS 13721-39-6 - Calbiochem

A broad spectrum potent inhibitor of protein tyrosine phosphatases.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: PTP Inhibitor X

Primary Target: Na+,K+-ATPase, acid , alkaline phosphatases, phosphofructokinase, and adenylate kinase
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567540
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Tableau de caractéristiques principal

CAS #Empirical Formula
13721-39-6Na₃VO₄

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      Description
      OverviewA broad spectrum potent inhibitor of protein tyrosine phosphatases. Also known to inhibit Na+,K+-ATPase, acid and alkaline phosphatases, phosphofructokinase, and adenylate kinase. Also inhibits the ATPase activity of the reconstituted binding protein-dependent ATP-Binding Cassette (ABC) transporter for maltose (MalFGK2) of Salmonella typhimurium in the micromolar range. Can be converted to pervanadate by hydrogen peroxide.
      Catalogue Number567540
      Brand Family Calbiochem®
      SynonymsPTP Inhibitor X
      References
      ReferencesHuyer, G., et al. 1997. J. Biol. Chem. 272, 843.
      Hunke, S., et al. 1995. Biochem. Biophys. Res. Commun. 216, 589.
      Levchuck, S.G., et al. 1994. Pediatric Res. 37, 382A.
      Fohr, K.J., et al. 1989. Biochem. J. 262, 83.
      Swarup, G., et al. 1982. Biochem. Biophys. Res. Commun. 107, 1104.
      Seargeant, L.E. and Stinson, R.A. 1979. Biochem. J. 181, 247.
      Product Information
      CAS number13721-39-6
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaNa₃VO₄
      Chemical formulaNa₃VO₄
      HS Code2841 90 30
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNa+,K+-ATPase, acid , alkaline phosphatases, phosphofructokinase, and adenylate kinase
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSYW1120000
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-36

      Do not breathe dust.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      567540-5GM 04055977266689

      Documentation

      Sodium Orthovanadate - CAS 13721-39-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Sodium Orthovanadate - CAS 13721-39-6 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      567540

      Références bibliographiques

      Aperçu de la référence bibliographique
      Huyer, G., et al. 1997. J. Biol. Chem. 272, 843.
      Hunke, S., et al. 1995. Biochem. Biophys. Res. Commun. 216, 589.
      Levchuck, S.G., et al. 1994. Pediatric Res. 37, 382A.
      Fohr, K.J., et al. 1989. Biochem. J. 262, 83.
      Swarup, G., et al. 1982. Biochem. Biophys. Res. Commun. 107, 1104.
      Seargeant, L.E. and Stinson, R.A. 1979. Biochem. J. 181, 247.

      Brochure

      Titre
      Protein Phosphatases Technical Bulletin

      Citations

      Titre
    • Amit V. Pandey and Walter L. Miller. (2005) Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17. Journal of Biological Chemistry 280, 13265-13271.
    • Hendrik Ungefroren, et al. (2001) FAP-1 in pancreatic cancer cells: functional and mechanistic studies on its inhibitory role in CD95-mediated apoptosis. Journal of Cell Science 114, 2735-2746.
      		•
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-October-2018 JSW
      SynonymsPTP Inhibitor X
      DescriptionA broad spectrum potent inhibitor of protein tyrosine phosphatases. Also known to inhibit Na+/K+ ATPase, acid and alkaline phosphatases, phosphofructokinase, and adenylate kinase. Most recently shown to inhibit ATPase activity of the reconstituted binding protein-dependent ATP-Binding Cassette (ABC) transporter for maltose (MalFGK2) of Salmonella typhimurium in the micromolar range. Can be converted to pervanadate by hydrogen peroxide.
      FormWhite to off-white solid
      CAS number13721-39-6
      RTECSYW1120000
      Chemical formulaNa₃VO₄
      SolubilityH₂O (10 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesHuyer, G., et al. 1997. J. Biol. Chem. 272, 843.
      Hunke, S., et al. 1995. Biochem. Biophys. Res. Commun. 216, 589.
      Levchuck, S.G., et al. 1994. Pediatric Res. 37, 382A.
      Fohr, K.J., et al. 1989. Biochem. J. 262, 83.
      Swarup, G., et al. 1982. Biochem. Biophys. Res. Commun. 107, 1104.
      Seargeant, L.E. and Stinson, R.A. 1979. Biochem. J. 181, 247.
      Citation
    • Amit V. Pandey and Walter L. Miller. (2005) Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17. Journal of Biological Chemistry 280, 13265-13271.
    • Hendrik Ungefroren, et al. (2001) FAP-1 in pancreatic cancer cells: functional and mechanistic studies on its inhibitory role in CD95-mediated apoptosis. Journal of Cell Science 114, 2735-2746.
      		•