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676492 VEGFR3 Kinase Inhibitor, MAZ51 - CAS 163655-37-6 - Calbiochem

VEGFR3 Kinase Inhibitor, MAZ51, CAS 163655-37-6, is a cell-permeable, reversible, ATP-competitive inhibitor of VEGF receptor tyrosine kinase. Blocks VEGF-C & VEGF-D-induced phosphorylation of VEGFR-3.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: MAZ51, 3-(4-Dimethylamino-naphthalen-1-ylmethylene)-1,3-dihydro-indol-2-one, Vascular Endothelial Growth Factor Receptor 3 Kinase Inhibitor, VEGFR Tyrosine Kinase Inhibitor XVI, VEGFR3 Kinase Inhibitor I

Primary Target: VEGF receptor tyrosine kinase
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676492
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Tableau de caractéristiques principal

CAS #Empirical Formula
163655-37-6C₂₁H₁₈N₂O

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676492-10MG
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      		 Ampoule plast. 10 mg
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      Description
      OverviewA cell-permeable 3-substituted indolin-2-one compound that acts as a reversible and ATP-competitive VEGF receptor tyrosine kinase inhibitor. At low concentration (≤5 µM), it specifically blocks VEGF-C- (Cat. No. 676476) and VEGF-D- (Cat. No. 676471) induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. It partially blocks VEGFR-2 phosphorylation only at higher concentrations (50 µM). This differential blocker may be useful for inhibiting lymphangiogenesis-dependent pathological process such as tumor metastasis. Not available for sale in Germany.
      Catalogue Number676492
      Brand Family Calbiochem®
      SynonymsMAZ51, 3-(4-Dimethylamino-naphthalen-1-ylmethylene)-1,3-dihydro-indol-2-one, Vascular Endothelial Growth Factor Receptor 3 Kinase Inhibitor, VEGFR Tyrosine Kinase Inhibitor XVI, VEGFR3 Kinase Inhibitor I
      References
      ReferencesKirkin, V., et al. 2001. Eur. J. Biochem. 268, 5530
      Product Information
      CAS number163655-37-6
      ATP CompetitiveY
      DeclarationNot available for sale in Germany.
      FormRed solid
      Hill FormulaC₂₁H₁₈N₂O
      Chemical formulaC₂₁H₁₈N₂O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationVEGFR3 Kinase Inhibitor, MAZ51, CAS 163655-37-6, is a cell-permeable, reversible, ATP-competitive inhibitor of VEGF receptor tyrosine kinase. Blocks VEGF-C & VEGF-D-induced phosphorylation of VEGFR-3.
      Biological Information
      Primary TargetVEGF receptor tyrosine kinase
      Primary Target IC<sub>50</sub>At low concentration (≤5 µM), it specifically blocks VEGF-C- and VEGF-D-induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells.
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      676492-10MG 04055977183689

      Documentation

      VEGFR3 Kinase Inhibitor, MAZ51 - CAS 163655-37-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      VEGFR3 Kinase Inhibitor, MAZ51 - CAS 163655-37-6 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      676492

      Références bibliographiques

      Aperçu de la référence bibliographique
      Kirkin, V., et al. 2001. Eur. J. Biochem. 268, 5530
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      SynonymsMAZ51, 3-(4-Dimethylamino-naphthalen-1-ylmethylene)-1,3-dihydro-indol-2-one, Vascular Endothelial Growth Factor Receptor 3 Kinase Inhibitor, VEGFR Tyrosine Kinase Inhibitor XVI, VEGFR3 Kinase Inhibitor I
      DescriptionA cell-permeable, 3-substituted, indolin-2-one compound that acts as a reversible and ATP-competitive inhibitor of VEGF receptor tyrosine kinase. At low concentrations (5 µM), reported to specifically block VEGF-C and VEGF-D-induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. Reported to partially block VEGFR-2 phosphorylation only at higher concentrations (50 µM). This differential inhibition may be useful for controlling lymphangiogenesis-dependent tumor metastasis and could, therefore, be of clinical significance for cancer therapy studies.
      FormRed solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number163655-37-6
      Chemical formulaC₂₁H₁₈N₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKirkin, V., et al. 2001. Eur. J. Biochem. 268, 5530