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324896 eIF-2α Inhibitor II, Sal003 - CAS 301359-91-1 - Calbiochem

The eIF-2α Inhibitor II, Sal003, also referenced under CAS 301359-91-1, controls the biological activity of eIF-2α. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 3-Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide, Sal003

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324896
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Tableau de caractéristiques principal

CAS #Empirical Formula
301359-91-1C₁₈H₁₅Cl₄N₃OS

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      Description
      OverviewA cell-permeable Salubrinal (Cat. No. 324895) analog that is reported to be more potent and soluble than Salubrinal. In addition to being a useful tool in studying elF2α-mediated cellular processes in cultures in vitro, enhanced elF2α phosphorylation by Sal003 treatment in the brain (40 pmol per animal) is shown to impair long-term memory in mice in vivo.
      Catalogue Number324896
      Brand Family Calbiochem®
      Synonyms3-Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide, Sal003
      References
      ReferencesRaven, J.F., et al. 2008. J. Biol. Chem. 283, 3097.
      Baltzis, D., et al. 2007. J. Biol. Chem. 282, 31675.
      Kazemi, S., et al. 2007. Mol. Biol. Cell 18, 3635.
      Costa-Mattioli, M., et al. 2007. Cell 129, 195.
      Robert, F., et al. 2006. Mol. Biol. Cell 17, 4632.
      Product Information
      CAS number301359-91-1
      FormOff-white solid
      Hill FormulaC₁₈H₁₅Cl₄N₃OS
      Chemical formulaC₁₈H₁₅Cl₄N₃OS
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      324896-5MG 04055977196238

      Documentation

      eIF-2α Inhibitor II, Sal003 - CAS 301359-91-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      eIF-2α Inhibitor II, Sal003 - CAS 301359-91-1 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      324896

      Références bibliographiques

      Aperçu de la référence bibliographique
      Raven, J.F., et al. 2008. J. Biol. Chem. 283, 3097.
      Baltzis, D., et al. 2007. J. Biol. Chem. 282, 31675.
      Kazemi, S., et al. 2007. Mol. Biol. Cell 18, 3635.
      Costa-Mattioli, M., et al. 2007. Cell 129, 195.
      Robert, F., et al. 2006. Mol. Biol. Cell 17, 4632.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-April-2011 RFH
      Synonyms3-Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide, Sal003
      DescriptionA cell-permeable Salubrinal (Cat. No. 324895) analog that is reported to be more potent and soluble than Salubrinal. In addition to being a useful tool in studying elF2α-mediated cellular processes in cultures in vitro, enhanced elF2α phosphorylation by Sal003 treatment in the brain (40 pmol per animal) is shown to impair long-term memory in mice in vivo.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number301359-91-1
      Chemical formulaC₁₈H₁₅Cl₄N₃OS
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Regulatory Review
      ReferencesRaven, J.F., et al. 2008. J. Biol. Chem. 283, 3097.
      Baltzis, D., et al. 2007. J. Biol. Chem. 282, 31675.
      Kazemi, S., et al. 2007. Mol. Biol. Cell 18, 3635.
      Costa-Mattioli, M., et al. 2007. Cell 129, 195.
      Robert, F., et al. 2006. Mol. Biol. Cell 17, 4632.