Millipore Sigma Vibrant Logo

203980 α-Bungarotoxin, Bungarus multicinctus - CAS 11032-79-4 - Calbiochem

Blocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor (Kd = 1 pM to 1 nM) but does not depress acetylcholine release from motor nerve endings.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
View Products on Sigmaaldrich.com
203980
Visualizza prezzi e disponibilità

Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
11032-79-4C₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁

Prezzi e disponibilità

Numero di catalogo DisponibilitàConfezionamento Qtà/conf Prezzo Quantità
203980-1MG
Verifica della disponibilità in corso...
—
Disponibilità limitata Disponibilità limitata
A magazzino 
Fuori produzione
Disponibili quantità limitate
La disponibilità deve essere confermata
    Prodotti rimanenti: riceverà un nostro avviso
      Prodotti rimanenti: riceverà un nostro avviso
      Will advise
      Contatti il Servizio Clienti
      Contact Customer Service

      		 Fiala di plastica 1 mg
      Ricerca del prezzo in corso...
      Non è stato possibile trovare il prezzo
      La quantità minima deve essere un multiplo di
      Maximum Quantity is
      Al termine dell'ordine Maggiori informazioni
      Lei ha salvato ()
       
      —
      Richiedi il prezzo
      		 —
      Description
      OverviewBlocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor (Kd = 1 pM to 1 nM) but does not depress acetylcholine release from motor nerve endings. Blocks nicotine-induced increase of intracellular Ca2+ in PC12 cells (IC50 = 310 nM), and prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-bungarotoxin on neuronal nAChR to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 >3 µM).
      Catalogue Number203980
      Brand Family Calbiochem®
      References
      ReferencesLopez, M.G., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14184.
      Zhang, Z.W., et al. 1994. Neuron 12, 167.
      Bambrick, L.L., and Gordon, T. 1992. J. Physiol. 449, 479.
      Lin, S.R., and Chang, C.C. 1992. Biochim. Biophys. Acta 1159, 255.
      Motomura, M., et al. 1992. Neurosci. Lett. 143, 139.
      Sorenson, E.M., and Chiappinelli, V.A. 1992. J. Comp. Neurol. 323, 1.
      Ruan, K.H., et al. 1990. 87, 6156.
      Product Information
      CAS number11032-79-4
      ATP CompetitiveN
      FormLyophilized solid
      Hill FormulaC₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁
      Chemical formulaC₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁
      HS Code3002 90 99
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMotor end-plate acetylcholine receptor
      Primary Target IC<sub>50</sub>Kd = 1 pM to 1 nM for motor end-plate acetylcholine receptor
      Physicochemical Information
      Cell permeableN
      ContaminantsNone detectable by IEF. Supplied as an acetate salt
      Peptide SequenceH-Ile-Val-Cys³-His-Thr-Thr-Ala-Thr-Ser-Pro-Ile-Ser-Ala-Val-Thr-Cys¹⁶-Pro-Pro-Gly-Glu-Asn-Leu-Cys²³-Tyr-Arg-Lys-Met-Trp-Cys²⁹-Asp-Ala-Phe-Cys³³-Ser-Ser-Arg-Gly-Lys-Val-Val-Glu-Leu-Gly-Cys⁴⁴-Ala-Ala-Thr-Cys⁴⁸-Pro-Ser-Lys-Lys-Pro-Tyr-Glu-Glu-Val-Thr-Cys⁵⁹-Cys⁶⁰-Ser-Thr-Asp-Lys-Cys⁶⁵-Asn-Pro-His-Pro-Lys-Gln-Arg-Pro-Gly-OH (disulfide bonds: 3 → 23; 16 → 44; 29 → 33; 48 → 59; 60 → 65)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSEI6201400
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      203980-1MG 04055977219944

      Documentation

      α-Bungarotoxin, Bungarus multicinctus - CAS 11032-79-4 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      α-Bungarotoxin, Bungarus multicinctus - CAS 11032-79-4 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      203980

      Riferimenti bibliografici

      Panoramica delle referenze
      Lopez, M.G., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14184.
      Zhang, Z.W., et al. 1994. Neuron 12, 167.
      Bambrick, L.L., and Gordon, T. 1992. J. Physiol. 449, 479.
      Lin, S.R., and Chang, C.C. 1992. Biochim. Biophys. Acta 1159, 255.
      Motomura, M., et al. 1992. Neurosci. Lett. 143, 139.
      Sorenson, E.M., and Chiappinelli, V.A. 1992. J. Comp. Neurol. 323, 1.
      Ruan, K.H., et al. 1990. 87, 6156.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2008 RFH
      DescriptionA polypeptide composed of 74 amino acids containing 5 disulfide bridges. Blocks neuromuscular transmission by irreversible binding to the motor end-plate acetylcholine receptor (Kd = 1 nM to 1 pM) but does not depress acetylcholine release from motor nerve endings. Blocks nicotine-induced augmentation in intracellular Ca2+ in PC12 cells (IC50 = 310 nM). Prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-Bungarotoxin on neuronal nAChR to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 > 3 µM).
      FormLyophilized solid
      CAS number11032-79-4
      RTECSEI6201400
      Chemical formulaC₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁
      Peptide SequenceH-Ile-Val-Cys³-His-Thr-Thr-Ala-Thr-Ser-Pro-Ile-Ser-Ala-Val-Thr-Cys¹⁶-Pro-Pro-Gly-Glu-Asn-Leu-Cys²³-Tyr-Arg-Lys-Met-Trp-Cys²⁹-Asp-Ala-Phe-Cys³³-Ser-Ser-Arg-Gly-Lys-Val-Val-Glu-Leu-Gly-Cys⁴⁴-Ala-Ala-Thr-Cys⁴⁸-Pro-Ser-Lys-Lys-Pro-Tyr-Glu-Glu-Val-Thr-Cys⁵⁹-Cys⁶⁰-Ser-Thr-Asp-Lys-Cys⁶⁵-Asn-Pro-His-Pro-Lys-Gln-Arg-Pro-Gly-OH (disulfide bonds: 3 → 23; 16 → 44; 29 → 33; 48 → 59; 60 → 65)
      ContaminantsNone detectable by IEF. Supplied as an acetate salt
      SolubilityH₂O or PBS
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 1488
      ReferencesLopez, M.G., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14184.
      Zhang, Z.W., et al. 1994. Neuron 12, 167.
      Bambrick, L.L., and Gordon, T. 1992. J. Physiol. 449, 479.
      Lin, S.R., and Chang, C.C. 1992. Biochim. Biophys. Acta 1159, 255.
      Motomura, M., et al. 1992. Neurosci. Lett. 143, 139.
      Sorenson, E.M., and Chiappinelli, V.A. 1992. J. Comp. Neurol. 323, 1.
      Ruan, K.H., et al. 1990. 87, 6156.