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100073 15-PGDH Inhibitor - CAS 1239610-60-6 - Calbiochem

The 15-PGDH Inhibitor controls the biological activity of 15-PGDH. This small molecule/inhibitor is primarily used for Membrane applications.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 5-(4-(2-Cyclohexylethoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione

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100073
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Tabella delle specifiche principali

CAS #Empirical Formula
1239610-60-6C₁₉H₂₃NO₄S

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100073-10MG
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      Description
      OverviewA cell-permeable, thiazolidinedione derivative that acts as a 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor (IC50 = 25 nM). It is shown to increase PGE2 levels in IL-1β-stimulated A549 cells, dose-dependently, in the range of 0–20 µM, and elicits cochlear blood flow (CBF) increase by 15% and 55% when applied intravenously to 250 g guinea pigs at 10 µg and 20 µg respectively.
      Catalogue Number100073
      Brand Family Calbiochem®
      Synonyms5-(4-(2-Cyclohexylethoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione
      References
      ReferencesWu, Y., et al. 2011. J. Med. Chem. 54, 5260.
      Product Information
      CAS number1239610-60-6
      FormYellow solid
      Hill FormulaC₁₉H₂₃NO₄S
      Chemical formulaC₁₉H₂₃NO₄S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      100073-10MG 04055977226195

      Documentation

      15-PGDH Inhibitor - CAS 1239610-60-6 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      15-PGDH Inhibitor - CAS 1239610-60-6 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      100073

      Riferimenti bibliografici

      Panoramica delle referenze
      Wu, Y., et al. 2011. J. Med. Chem. 54, 5260.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-June-2012 JSW
      Synonyms5-(4-(2-Cyclohexylethoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione
      DescriptionA cell-permeable, thiazolidinedione derivative that acts as a 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor (IC50 = 25 nM). It is shown to increase PGE2 levels in IL-1β-stimulated A549 cells, dose-dependently, in the range of 0–20 µM, and elicits cochlear blood flow (CBF) increase by 15% and 55% when applied intravenously to 250 g guinea pigs at 10 µg and 20 µg respectively.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1239610-60-6
      Chemical formulaC₁₉H₂₃NO₄S
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (100 mg/ml; clear, pale yellow solution)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesWu, Y., et al. 2011. J. Med. Chem. 54, 5260.