Millipore Sigma Vibrant Logo

MABE355 Anti-ADAR2 Antibody, clone 2D1.1

Anti-ADAR2 Antibody, clone 2D1.1 is an antibody against ADAR2 for use in western blotting & ICC.

Anti-ADAR2 Antibody, clone 2D1.1: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: NUP98, ADAR2 UniProt Number: P52948
View Products on Sigmaaldrich.com
MABE355
100 µg  
Ricerca del prezzo in corso...
Non è stato possibile trovare il prezzo
La quantità minima deve essere un multiplo di
Maximum Quantity is
Al termine dell'ordine Maggiori informazioni
Lei ha salvato ()
 
—
Richiedi il prezzo
—
Disponibilità limitata Disponibilità limitata
A magazzino 
Fuori produzione
Disponibili quantità limitate
La disponibilità deve essere confermata
    Prodotti rimanenti: riceverà un nostro avviso
      Prodotti rimanenti: riceverà un nostro avviso
      Will advise
      Contatti il Servizio Clienti
      Contact Customer Service

      Offerte speciali

       

      Contatti il Servizio Clienti

      Panoramica

      Replacement Information

      Offerte speciali

      100% Performance Guaranteed

      Tabella delle specifiche principali

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABE355
      DescriptionAnti-ADAR2 Antibody, clone 2D1.1
      Alternate Names
      • Nuclear pore complex protein Nup98-Nup96
      • 98 kDa nucleoporin
      • Nucleoporin Nup98
      • Nup98
      Background InformationADAR, also known as Nuclear pore protein 96 (NUP96) named after its molecular weight, or often in the literature as its yeast name, Nup145C, is one of them and NUP96 is made from the autocatalytic cleavage of a larger precursor protein named the Nuclear Pore Complex protein Nup98-Nup96, which also happens to be the source of NUP98 another important nuclear pore protein. NUC96 is found on both the nuclear and cytoplasmic sides of the NPC, whereas NUP98 apparently shuttles between the cytoplasmic side and the nucleoplasmic side of the NPC. Nup96 is part of a NP heptameric complex in the nuclear pore complex. Nup96 complexes with Sec13 in the middle of the heptamer complex. The function of the heptamer is to coat the curvature of the nuclear pore complex between the inner and outer nuclear membranes. Nup96 is predicted to be an alpha helical solenoid. The interaction between Nup96 and Sec13 is at the point of curvature in the heptameric complex. Interestingly, NUP96 and NUP98 also have a crucial role in the function of the immune system and are up regulated by interferons in response to viral infections. A heterozygous mutation in NUP96 has been shown to affect the expression of interferon-regulated genes and to disrupt the normal function of macrophages, and B and T lymphocytes, with no detectable gross pathological abnormalities in other organs. Moreover, the role of Nup96 in the immune response seems to be evolutionarily conserved, as NUP96 in Arabidopsis thaliana has also been shown to be required for the basal defense and resistance responses mediated by plant immune sensors.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-ADAR2 Antibody, clone 2D1.1 is an antibody against ADAR2 for use in western blotting & ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A 1:250 dilution from a representative lot detected ADAR2 in HeLa cells.

      Alexa Fluor® is a registered trademark of Life Technologies®.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human ADAR2.
      Clone2D1.1
      Concentration1 mg/mL
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NUP98
      • ADAR2
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~98 kDa observed. Uniprot describes 6 isoforms due to alternative splicing at 198 kDa, 187 kDa, 98 kDa, 96 kDa, 196 kDa, and 186 kDa. Uniprot also describes that the Nuclear pore complex protein Nup98-Nup96 is cleaved into a 98 kDa and a 96 kDa form. Uncharacterized band(s) may be observed in some cell lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected ADAR2 in 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      MABE355 04053252975660

      Prodotti e applicazioni correlate

      Related Products

      Numero di catalogo Descrizione  
      MABE1040 Anti-Nup98 Antibody, clone 2H10 Prezzi e disponibilità

      Categorie

      Life Science Research > Antibodies and Assays > Primary Antibodies