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MABN864 Anti-Potassium Channel Kir4.1 Antibody, clone 9C9.2

Anti-Potassium Channel Kir4.1 Antibody, clone 9C9.2 is an antibody against Potassium Channel Kir4.1 for use in Western Blotting, Immunohistochemistry (Paraffin).

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Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: KCNJ10, SESAMES UniProt Number: P78508
MABN864
100 μg  
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      Tabella delle specifiche principali

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN864
      DescriptionAnti-Potassium Channel Kir4.1 Antibody, clone 9C9.2
      Alternate Names
      • ATP-sensitive inward rectifier potassium channel 10
      • ATP-dependent inwardly rectifying potassium channel Kir4.1
      • Inward rectifier K(+) channel Kir1.2
      • Potassium channel, inwardly rectifying subfamily J member 10
      Background InformationATP-sensitive inward rectifier potassium channel 10 (UniProt P78508; also known as ATP-dependent inwardly rectifying potassium channel Kir4.1, Inward rectifier K(+) channel Kir1.2, Potassium channel, inwardly rectifying subfamily J member 10) is encoded by the KCNJ10 (also known as SESAMES) gene (Gene ID 3766) in human. Inward rectifier K+ channels (Kirs) modulate cell membrane potential and are classified as K+ transport channels (Kir1.x, Kir4.x, Kir5.x, Kir7.x), classic Kir (Kir2.x), G-protein-gated Kirs, and ATP-sensitive Kirs. Kirs mediate diverse physiological functions of both excitable and nonexcitable epithelial cells, such as cell adhesion-migration, volume regulation, apoptosis, and proliferation. Kir4.1 is widely expressed in the kidney distal convoluted tubules and neural glia cells, its expression in the cochlea and retina is also reported. Kir4.1 modulates plasma K+ by favoring K+ exit, and inhibition of Kir4.1 results in membrane depolarization. KCNJ10 gene mutations are known causes of SeSAMES (seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance syndrome). Human Kir4.1 is a 379-amino acid multi-pass membrane (a.a. 65-89, 115-126, 143-164) protein containg two small extraceullar regions (a.a. 90-114 and 134-142), a pore-forming domain (a.a. 134-142), and having both N- and C-terminal exposed intracellularly (a.a. 1-64 and a.a. 165-379).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgMκ antibody in PBS with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Potassium Channel Kir4.1 Antibody, clone 9C9.2 is an antibody against Potassium Channel Kir4.1 for use in Western Blotting, Immunohistochemistry (Paraffin).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesWestern Blotting Analysis: 2.0 µg/mL from a representative lot detected potassium channel Kir4.1 in 10 µg of mouse cerebellum tissue lysate.
      Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected potassium channel Kir4.1 immunoreactivity in the molecular layer of human cerebellum tissue sections.
      Immunohistochemistry Analysis: A 1:25 dilution from a representative lot immunostained glial cells near ventricles in rat brain and astrocytes in the white matter of human cerebellum tissue sections.
      Biological Information
      ImmunogenKLH-conjugated linear peptides corresponding to sequences from the first extracellular domain and the C-terminal cytoplasmic tail of human potassium channel Kir4.1.
      Clone9C9.2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 9C9.2 detects potassium channel Kir4.1.
      IsotypeIgMκ
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KCNJ10
      • SESAMES
      UniProt Number
      Molecular Weight~49 kDa observed. Target band size appears larger than the calculated molecular weight of 42.51 kDa due to glycosylation. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting Analysis in mouse brain tissue lysate:

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected potassium channel Kir4.1 in 10 µg of mouse brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      MABN864 04055977332216