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ABE1317 Anti-phospho Cyclin-dependent kinase 7 (Thr170) Antibody

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ABE1317
100 µg  
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      Tabella delle specifiche principali

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, ChIPRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE1317
      DescriptionAnti-phospho Cyclin-dependent kinase 7 (Thr170) Antibody
      Alternate Names
      • Cyclin-dependent kinase 7
      • 39 kDa protein kinase
      • p39 Mo15
      • CDK-activating kinase 1
      • Cell division protein kinase 7
      • Serine/threonine-protein kinase 1
      • TFIIH basal transcription factor complex kinase subunit
      Background InformationCyclin-dependent kinases (CDKs) are activated by the binding to a cyclin protein and they mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Cyclin-dependent kinase 7 (CDK7), also known as Cyclin-dependent kinase 7, or 39 kDa protein kinase (p39-Mo15), CDK-activating kinase 1, Cell division protein kinase 7, Serine/threonine-protein kinase 1, or TFIIH basal transcription factor complex kinase subunit, and encoded by the gene CDK7/CAK/CAK1/CDKN7/MO15/STK1, is a serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CDK7 is inactivated by phosphorylation, thus Cyclin-dependent kinase 7 (Thr107) is an inactive CDK7 protein.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-phospho Cyclin-dependent kinase 7 (Thr170) antibody is validated for use in western blotting & ChIP for the detection of phospho Cyclin-dependent kinase 7 (Thr170).
      Key Applications
      • Western Blotting
      • Chromatin Immunoprecipitation (ChIP)
      Application NotesWestern Blotting Analysis: A representative lot detected phospho Cyclin-dependent kinase 7 (Thr170) in Cdk7 and Csk1 kinase (Larochelle, S., et al. (2012). Nature Struc. Mole. Biol. 19(11):1108-1115).
      Chromatin Immunoprecipitation Analysis: A representative lot immunoprecipitated phospho Cyclin-dependent kinase 7 (Thr170) in HCT116 cell lysate treated with doxorubicin (Larochelle, S., et al. (2012). Nature Struc. Mole. Biol. 19(11):1108-1115).
      Biological Information
      ImmunogenLinear peptide corresponding to human phosphorylated phospho Cyclin-dependent kinase 7 (Thr170).
      EpitopePhosphorylated T107
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CDK7
      • CAK
      • CAK1
      • CDKN7
      • MO15
      • STK1
      Modifications
      • Phosphorylation
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~ 39 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in A431 cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected phospho Cyclin-dependent kinase 7 (Thr170) in 10 µg of A431 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      ABE1317 04053252956157

      Documentation

      Anti-phospho Cyclin-dependent kinase 7 (Thr170) Antibody MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Anti-phospho Cyclin-dependent kinase 7 (Thr170) Antibody Certificati d'Analisi

      TitoloNumero di lotto
      Anti-phospho Cyclin-dependent kinase 7 (Thr170) - Q2384857 Q2384857
      Anti-phospho Cyclin-dependent kinase 7 (Thr170) - 3426689 3426689
      Anti-phospho Cyclin-dependent kinase 7 (Thr170) - 3759981 3759981
      Anti-phospho Cyclin-dependent kinase 7 (Thr170) - 3995144 3995144
      Anti-phospho Cyclin-dependent kinase 7 (Thr170) - 4180371 4180371

      Riferimenti bibliografici

      Panoramica dei riferimenti bibliograficiCodice d'identificazione nel Pub Med
      Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II.
      Larochelle, S; Amat, R; Glover-Cutter, K; Sansó, M; Zhang, C; Allen, JJ; Shokat, KM; Bentley, DL; Fisher, RP
      Nature structural & molecular biology  19  1108-15  2011

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