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208921 Calmodulin Kinase IINtide, Myristoylated - Calbiochem

The myristoylated form of CaMK IINtide.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Myr-N-GGGKRPPKLGQIGRAKRVVIEDDRIDDVLK-OH

Primary Target: Calmodulin-Dependent Protein Kinase (CaM Kinase)-2
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208921
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₂₅₆H₂₇₅N₄₇O₄₃

Prezzi e disponibilità

Numero di catalogo DisponibilitàConfezionamento Qtà/conf Prezzo Quantità
208921-1MG
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      Description
      OverviewThe myristoylated form of CaMK IINtide (Cat. No. 208920). The peptide has been modified at the amino terminal lysine with the addition of three glycine residues and myristoylated to improve cell-permeability.
      Catalogue Number208921
      Brand Family Calbiochem®
      SynonymsMyr-N-GGGKRPPKLGQIGRAKRVVIEDDRIDDVLK-OH
      References
      ReferencesSodering, T.R., et al. 2001. J. Biol. Chem. 276, 3719.
      Chang, B.H., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 10890.
      Pereda, A.E., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13272.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₂₅₆H₂₇₅N₄₇O₄₃
      Chemical formulaC₂₅₆H₂₇₅N₄₇O₄₃
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCalmodulin-Dependent Protein Kinase (CaM Kinase)-2
      Primary Target IC<sub>50</sub>50 nM against cam Kinase-2
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceMyr-N-Gly-Gly-Gly-Lys-Arg-Pro-Pro-Lys-Leu-Gly-Gln-Ile-Gly-Arg-Ala-Lys-Arg-Val-Val-Ile-Glu-Asp-Asp-Arg-Ile-Asp-Asp-Val-Leu-Lys-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at-20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      208921-1MG 04055977219555

      Documentation

      Calmodulin Kinase IINtide, Myristoylated - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Calmodulin Kinase IINtide, Myristoylated - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      208921

      Riferimenti bibliografici

      Panoramica delle referenze
      Sodering, T.R., et al. 2001. J. Biol. Chem. 276, 3719.
      Chang, B.H., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 10890.
      Pereda, A.E., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13272.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-May-2008 RFH
      SynonymsMyr-N-GGGKRPPKLGQIGRAKRVVIEDDRIDDVLK-OH
      DescriptionThe myristoylated form of CaMK IINtide (Cat. No. 208920), a potent, specific inhibitor of Ca2+/Calmodulin kinase II (CaMK II) (IC50 = 50 nM for total and Ca2+-independent CaMK II activity). The peptide sequence corresponds to the inhibitory domain of the CaMK II inhibitory protein, CaMK IIN. Exhibits inhibitory activity across converged species, including rat brain, goldfish brain, and Drosophila (IC50 = 100-400 nM). Shown to completely inhibit the phosphorylation of GluR1 fusion protein at a concentration of 1 µM. Does not inhibit CaMK I, CaMK IV, CaMKK, PKA, or PKC. The peptide has been modified at the amino terminal lysine with the addition of three glycine residues and myristoylated to improve cell-permeability.
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₅₆H₂₇₅N₄₇O₄₃
      Peptide SequenceMyr-N-Gly-Gly-Gly-Lys-Arg-Pro-Pro-Lys-Leu-Gly-Gln-Ile-Gly-Arg-Ala-Lys-Arg-Val-Val-Ile-Glu-Asp-Asp-Arg-Ile-Asp-Asp-Val-Leu-Lys-OH
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at-20°C.
      Toxicity Standard Handling
      ReferencesSodering, T.R., et al. 2001. J. Biol. Chem. 276, 3719.
      Chang, B.H., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 10890.
      Pereda, A.E., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13272.