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400010 Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem

The Caspase-1 Inhibitor I, also referenced under CAS 143313-51-3, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: IL-1β Converting Enzyme (ICE) Inhibitor I, Ac-YVAD-CHO, L-709049

Primary Target: caspase-1, human recombinant
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400010
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Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
143313-51-3C₂₃H₃₂N₄O₈

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      Description
      OverviewA potent, specific, and reversible inhibitor of caspase-1 (Ki = 200 pM for human recombinant caspase-1), caspase-4, and caspase-5. Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.
      Catalogue Number400010
      Brand Family Calbiochem®
      SynonymsIL-1β Converting Enzyme (ICE) Inhibitor I, Ac-YVAD-CHO, L-709049
      References
      ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Los, M., et al. 1995. Nature 375, 81.
      Walker, N.P.C., et al. 1994. Cell 78, 343.
      Wilson, K.P., et al. 1994. Nature 370, 270.
      Thornberry, N.A., et al. 1992. Nature 356, 768.
      Product Information
      CAS number143313-51-3
      ATP CompetitiveN
      FormWhite powder
      Hill FormulaC₂₃H₃₂N₄O₈
      Chemical formulaC₂₃H₃₂N₄O₈
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcaspase-1, human recombinant
      Primary Target K<sub>i</sub>200 pM for human recombinant caspase-1
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceAc-Tyr-Val-Ala-Asp-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      400010-5MG 04055977212617

      Documentation

      Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      400010

      Riferimenti bibliografici

      Panoramica delle referenze
      Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Los, M., et al. 1995. Nature 375, 81.
      Walker, N.P.C., et al. 1994. Cell 78, 343.
      Wilson, K.P., et al. 1994. Nature 370, 270.
      Thornberry, N.A., et al. 1992. Nature 356, 768.

      Brochure

      Titolo
      Caspases and other Apoptosis Related Tools Brochure
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-July-2014 JSW
      SynonymsIL-1β Converting Enzyme (ICE) Inhibitor I, Ac-YVAD-CHO, L-709049
      DescriptionInterleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. ICE inhibitor I is a potent, specific, and reversible inhibitor of ICE (Ki = 200 pM for human recombinant ICE). Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.
      FormWhite powder
      CAS number143313-51-3
      Chemical formulaC₂₃H₃₂N₄O₈
      Peptide SequenceAc-Tyr-Val-Ala-Asp-CHO
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml) or H₂O
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Los, M., et al. 1995. Nature 375, 81.
      Walker, N.P.C., et al. 1994. Cell 78, 343.
      Wilson, K.P., et al. 1994. Nature 370, 270.
      Thornberry, N.A., et al. 1992. Nature 356, 768.

      Prodotti e applicazioni correlate

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      Categorie

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Apoptosis/Necrosis Inhibitors > Caspase Inhibitors