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287840 Diclofenac Sodium - CAS 15307-79-6 - Calbiochem

A cell-permeable, non-selective cyclooxygenase inhibitor (IC₅₀ = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na

Primary Target: COX-1
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      Panoramica

      Replacement Information

      Tabella delle specifiche principali

      CAS #Empirical Formula
      15307-79-6C₁₄H₁₀Cl₂NO₂ · Na
      Description
      OverviewA cell-permeable, non-selective cyclooxygenase inhibitor (IC50 = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity. Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Also inhibits liver phenol sulfotransferase activity (IC50 = 9.5 µM).
      Catalogue Number287840
      Brand Family Calbiochem®
      Synonyms2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na
      References
      ReferencesKato, M., et al. 2001. J. Pharm. Pharmacol. 53, 1679.
      Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
      Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81.
      Merlos, M., et al. 1996. Inflamm. Res. 45, 20.
      Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473.
      Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479.
      Product Information
      CAS number15307-79-6
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₄H₁₀Cl₂NO₂ · Na
      Chemical formulaC₁₄H₁₀Cl₂NO₂ · Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCOX-1
      Primary Target IC<sub>50</sub>60 nM and 200 nM for ovine COX-1 and COX-2 respectively; 9.5 µM against liver phenol sulfotransferase activity
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSAG6330000
      Safety Information
      R PhraseR: 23/24/25-63

      Toxic by inhalation, in contact with skin and if swallowed.
      Possible risk of harm to the unborn child.
      S PhraseS: 22-36

      Do not breathe dust.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      287840 0

      Documentation

      Diclofenac Sodium - CAS 15307-79-6 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Diclofenac Sodium - CAS 15307-79-6 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      287840

      Riferimenti bibliografici

      Panoramica delle referenze
      Kato, M., et al. 2001. J. Pharm. Pharmacol. 53, 1679.
      Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
      Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81.
      Merlos, M., et al. 1996. Inflamm. Res. 45, 20.
      Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473.
      Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479.

      Brochure

      Titolo
      Alzheimer's Disease Brochure & Technical Guide
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-April-2008 RFH
      Synonyms2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na
      DescriptionA potent non-steroidal anti-inflammatory drug that inhibits both COX-1 (IC50 = 76 nM) and COX-2 (IC50 = 26 nM) activities. Also inhibits liver phenol sulfotransferase activity (IC50 ~9.5 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation.
      FormWhite solid
      CAS number15307-79-6
      RTECSAG6330000
      Chemical formulaC₁₄H₁₀Cl₂NO₂ · Na
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityH₂O (25 mg/ml)
      Storage +15°C to +30°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 3081
      ReferencesKato, M., et al. 2001. J. Pharm. Pharmacol. 53, 1679.
      Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
      Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81.
      Merlos, M., et al. 1996. Inflamm. Res. 45, 20.
      Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473.
      Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479.