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341305 Fasentin - CAS 392721-37-8 - Calbiochem

Fasentin - CAS 392721-37-8 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Glucose Transporter Inhibitor, 6094911, N-(4-Chloro-3-(trifluoromethyl)phenyl)-3-oxobutanamide

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341305
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341305-25MG
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      Description
      OverviewA cell-permeable oxobutananilide compound that is predicted to interact with Glut (Glucose Transporter) at an intracellular site based on a virtual docking study and shown to inhibit Glut-mediated cellular glucose uptake (50% and 80% inhibition of 2-deoxy-D-glucose uptake in Glut1- and Glut4-overexpressing L6 myoblasts, respectively, at 300 µM). Fas-resistant cell lines that are made Fas-responsive upon medium glucose deprivation are also shown to be sensitized by Fasentin to Fas-mediated cell death (ED50 = 35 µM in PPC-1 cultures), while cells that remain Fas-resistant upon glucose deprivation, e.g. DU145, are shown not to be sensitized by Fasentin to Fas-mediated death.
      Catalogue Number341305
      Brand Family Calbiochem®
      SynonymsGlucose Transporter Inhibitor, 6094911, N-(4-Chloro-3-(trifluoromethyl)phenyl)-3-oxobutanamide
      References
      ReferencesWood, T.E., et al. 2008. Mol. Cancer Ther. 7, 3546
      Schimmer, A.D., et al. 2006. Cancer Res. 66, 2367.
      Product Information
      CAS number392721-37-8
      FormOff-white solid
      Hill FormulaC₁₁H₉ClF₃NO₂
      Chemical formulaC₁₁H₉ClF₃NO₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -2°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      341305-25MG 04055977215649

      Documentation

      Fasentin - CAS 392721-37-8 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Fasentin - CAS 392721-37-8 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      341305

      Riferimenti bibliografici

      Panoramica delle referenze
      Wood, T.E., et al. 2008. Mol. Cancer Ther. 7, 3546
      Schimmer, A.D., et al. 2006. Cancer Res. 66, 2367.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-April-2011 RFH
      SynonymsGlucose Transporter Inhibitor, 6094911, N-(4-Chloro-3-(trifluoromethyl)phenyl)-3-oxobutanamide
      DescriptionA cell-permeable oxobutananilide compound that is predicted to interact with Glut (Glucose Transporter) at an intracellular site based on a virtual docking study and shown to inhibit Glut-mediated cellular glucose uptake (50% and 80% inhibition of 2-deoxy-D-glucose uptake in Glut1- and Glut4-overexpressing L6 myoblasts, respectively, at 300 µM). Fas-resistant cell lines that are made Fas-responsive upon medium glucose deprivation are also shown to be sensitized by Fasentin to Fas-mediated cell death (ED50 = 35 µM in PPC-1 cultures), while cells that remain Fas-resistant upon glucose deprivation, e.g. DU145, are shown not to be sensitized by Fasentin to Fas-mediated death.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number392721-37-8
      Chemical formulaC₁₁H₉ClF₃NO₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (20 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -2°C.
      Toxicity Standard Handling
      ReferencesWood, T.E., et al. 2008. Mol. Cancer Ther. 7, 3546
      Schimmer, A.D., et al. 2006. Cancer Res. 66, 2367.