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444288 MMP-2 Inhibitor III - CAS 704888-90-4 - Calbiochem

The MMP-2 Inhibitor III, also referenced under CAS 704888-90-4, controls the biological activity of MMP-2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: (2-((Isopropoxy)-(1,1ʹ-biphenyl-4-ylsulfonyl)-amino))-N-hydroxyacetamide

Primary Target: MMP-2
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444288
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Tabella delle specifiche principali

CAS #Empirical Formula
704888-90-4C₁₇H₂₀N₂O₅S

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444288-5MG
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      Description
      OverviewA cell-permeable biphenylsulfonamido-hydroxamate compound that acts a potent and Zn2+-binding site-targeting inhibitor of MMP-2 (IC50 = 12 nM). It exhibits good selectivity over MMP-9 and MMP-3 (IC50 = 0.2 and 4.5 µM, respectively) and shows practically no effect towards MMP-1 and MMP-7 (IC50 > 50 µM). Shown to effectively suppress the invasiveness of HT1080 sarcoma cells grown on matrigel.
      Catalogue Number444288
      Brand Family Calbiochem®
      Synonyms(2-((Isopropoxy)-(1,1ʹ-biphenyl-4-ylsulfonyl)-amino))-N-hydroxyacetamide
      References
      ReferencesTuccinardi, T., et al. 2006. Bioorg. Med. Chem. 14, 4260.
      Rossello, A., et al. 2004. Bioorg. Med. Chem. 12, 2441.
      Product Information
      CAS number704888-90-4
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₇H₂₀N₂O₅S
      Chemical formulaC₁₇H₂₀N₂O₅S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMMP-2
      Primary Target IC<sub>50</sub>12 nM against MMP-2
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      444288-5MG 04055977186055

      Documentation

      MMP-2 Inhibitor III - CAS 704888-90-4 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      MMP-2 Inhibitor III - CAS 704888-90-4 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      444288

      Riferimenti bibliografici

      Panoramica delle referenze
      Tuccinardi, T., et al. 2006. Bioorg. Med. Chem. 14, 4260.
      Rossello, A., et al. 2004. Bioorg. Med. Chem. 12, 2441.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      Synonyms(2-((Isopropoxy)-(1,1ʹ-biphenyl-4-ylsulfonyl)-amino))-N-hydroxyacetamide
      DescriptionA cell-permeable biphenylsulfonamido-hydroxamate compound that acts a potent and Zn2+-binding site-targeting inhibitor of MMP-2 (IC50 = 12 nM). It exhibits good selectivity over MMP-9 and MMP-3 (IC50 = 0.2 and 4.5 µM, respectively) and shows practically no effect towards MMP-1 and MMP-7 (IC50 > 50 µM). Shown to effectively suppress the invasiveness of HT1080 sarcoma cells grown on matrigel.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number704888-90-4
      Chemical formulaC₁₇H₂₀N₂O₅S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (200 mg/ml) or Methanol (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesTuccinardi, T., et al. 2006. Bioorg. Med. Chem. 14, 4260.
      Rossello, A., et al. 2004. Bioorg. Med. Chem. 12, 2441.