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517301 P-Glycoprotein Inhibitor, C-4 - CAS 864426-22-2 - Calbiochem

The P-Glycoprotein Inhibitor, C-4 controls the biological activity of P-Glycoprotein. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: (E)-4-Chloro-N-(3-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide, C-4

Primary Target: P-Glycoprotein
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517301
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Tabella delle specifiche principali

CAS #Empirical Formula
864426-22-2C₂₃H₁₈ClNO₄

Prezzi e disponibilità

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517301-10MG
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      Description
      OverviewA cell-permeable cinnamoyl compound that reversibly inhibits P-gp (P-glycoprotein) efflux function and reverses the MDR (multidrug resistance) phenotype with no noticeable effect on P-gp expression. Shown to significantly enhance Paclitaxel- (Cat. No. 580555) and Vincristine- (Cat. No. 677181) induced cytotoxicity as well as apoptosis in P-gp expressing KBV20C cells.
      Catalogue Number517301
      Brand Family Calbiochem®
      Synonyms(E)-4-Chloro-N-(3-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide, C-4
      References
      ReferencesKim, Y.K., et al. 2007. Biochem. Biophys. Res. Commun. 355, 136.
      Woo, H.B., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3782.
      Product Information
      CAS number864426-22-2
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₂₃H₁₈ClNO₄
      Chemical formulaC₂₃H₁₈ClNO₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetP-Glycoprotein
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      517301-10MG 04055977271874

      Documentation

      P-Glycoprotein Inhibitor, C-4 - CAS 864426-22-2 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      P-Glycoprotein Inhibitor, C-4 - CAS 864426-22-2 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      517301

      Riferimenti bibliografici

      Panoramica delle referenze
      Kim, Y.K., et al. 2007. Biochem. Biophys. Res. Commun. 355, 136.
      Woo, H.B., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3782.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-January-2008 JSW
      Synonyms(E)-4-Chloro-N-(3-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide, C-4
      DescriptionA cell-permeable cinnamoyl compound that reversibly inhibits P-gp (P-glycoprotein) efflux function and reverses the MDR (multidrug resistance) phenotype with no noticeable effect on P-gp expression. Shown to significantly enhance Paclitaxel- (Cat. No. 580555) and Vincristine- (Cat. No. 677181) induced cytotoxicity as well as apoptosis in P-gp expressing KBV20C cells.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number864426-22-2
      Chemical formulaC₂₃H₁₈ClNO₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKim, Y.K., et al. 2007. Biochem. Biophys. Res. Commun. 355, 136.
      Woo, H.B., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3782.