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567300 SKF-525A, Hydrochloride - CAS 62-68-0 - Calbiochem

Cell permeable. Blocks glibenclamide-sensitive K+ channels. Inhibits neuronal nitric oxide synthase. Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Proadifen

Primary Target: nNOS
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567300
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Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
62-68-0C₂₃H₃₁NO₂ . HCl

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567300-1GM
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      Description
      OverviewCell permeable. Blocks glibenclamide-sensitive K+ channels. Inhibits neuronal nitric oxide synthase (IC50 = 90 µM). Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system. Stimulates endothelial cell prostacyclin production while inhibiting platelet thromboxane synthesis. Potentiates the action of many drugs in vivo.
      Catalogue Number567300
      Brand Family Calbiochem®
      SynonymsProadifen
      References
      ReferencesHecker, M., et al. 1994. J. Neurochem. 62, 1524.
      Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol. 252, 117.
      Khan, S., et al. 1993. Biochem. Pharmacol. 45, 439.
      Boeynaems, J.M., et al. 1986. Prostaglandins 32, 145.
      Lee, C.H., et al. 1976. J. Pharmacol. Exp. Ther. 198, 347.
      Grasdalen, J., et al. 1975. FEBS Lett. 60, 240.
      Product Information
      CAS number62-68-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₃H₃₁NO₂ . HCl
      Chemical formulaC₂₃H₃₁NO₂ . HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetnNOS
      Primary Target IC<sub>50</sub>90 µM against neuronal nitric oxide synthase
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSYV7175000
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator(4°C). Stock solutions are stable for up to 6 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      567300-1GM 04055977267181

      Documentation

      SKF-525A, Hydrochloride - CAS 62-68-0 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      SKF-525A, Hydrochloride - CAS 62-68-0 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      567300

      Riferimenti bibliografici

      Panoramica delle referenze
      Hecker, M., et al. 1994. J. Neurochem. 62, 1524.
      Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol. 252, 117.
      Khan, S., et al. 1993. Biochem. Pharmacol. 45, 439.
      Boeynaems, J.M., et al. 1986. Prostaglandins 32, 145.
      Lee, C.H., et al. 1976. J. Pharmacol. Exp. Ther. 198, 347.
      Grasdalen, J., et al. 1975. FEBS Lett. 60, 240.

      Brochure

      Titolo
      Pathways and Biomarkers of Oxidative Stress
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-September-2008 RFH
      SynonymsProadifen
      DescriptionCell permeable. Blocks glibenclamide-sensitive K+ channels (IC50 = 4.4 µM). Inhibits neuronal nitric oxide synthase (IC50 = 90 µM). Also inhibits hepatic drug metabolism by inhibiting the cytochrome P-450 system. Stimulates endothelial cell prostocyclin production while inhibiting platelet thromboxane synthesis. Potentiates the effect of many drugs in vivo.
      FormWhite solid
      CAS number62-68-0
      RTECSYV7175000
      Chemical formulaC₂₃H₃₁NO₂ . HCl
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityH₂O (20 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator(4°C). Stock solutions are stable for up to 6 months at 4°C.
      Toxicity Harmful
      ReferencesHecker, M., et al. 1994. J. Neurochem. 62, 1524.
      Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol. 252, 117.
      Khan, S., et al. 1993. Biochem. Pharmacol. 45, 439.
      Boeynaems, J.M., et al. 1986. Prostaglandins 32, 145.
      Lee, C.H., et al. 1976. J. Pharmacol. Exp. Ther. 198, 347.
      Grasdalen, J., et al. 1975. FEBS Lett. 60, 240.